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PMID: 1681546 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 20 ·1991-10-15 ·Pages 8900-4

Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH

Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

MeSH Terms
Amino Acid Sequence Animals Cell Line Chromosome Banding Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 7 DNA, Neoplasm/genetics,isolation & purification DNA-Binding Proteins/genetics Genes, Homeobox Homeodomain Proteins Humans Introns Leukemia-Lymphoma, Adult T-Cell/genetics Mice Molecular Sequence Data Oncogene Proteins/genetics Oncogenes Proto-Oncogene Proteins Receptors, Antigen, T-Cell, alpha-beta/genetics Receptors, Antigen, T-Cell, gamma-delta/genetics Restriction Mapping Sequence Homology, Nucleic Acid T-Lymphocytes/physiology Translocation, Genetic
Chemicals
DNA, Neoplasm DNA-Binding Proteins Homeodomain Proteins Oncogene Proteins Proto-Oncogene Proteins Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta Tlx1 protein, mouse TLX1 protein, human
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Kennedy M A
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Gonzalez-Sarmiento R
Kees U R
Lampert F
Dear N
Boehm T
Rabbitts T H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.20.8900
Published
1991-10-15
Pages
8900-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52618
Subset
IM
Databases
GENBANK
M75952, M75953
External Links
PubMed source DOI: 10.1073/pnas.88.20.8900 PMC Full Text View journal details
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