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PMID: 16816431 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Effects of trans-acting genetic modifiers on meiotic recombination across the a1-sh2 interval of maize.

Genetics ·Vol. 174 ·No. 1 ·2006-09-00 ·Pages 101-12

Yandeau-Nelson MD, Nikolau BJ, Schnable PS

Abstract

Meiotic recombination rates are potentially affected by cis- and trans-acting factors, i.e., genotype-specific modifiers that do or do not reside in the recombining interval, respectively. Effects of trans modifiers on recombination across the approximately 140-kb maize a1-sh2 interval of chromosome 3L were studied in the absence of polymorphic cis factors in three genetically diverse backgrounds into which a sequence-identical a1-sh2 interval had been introgressed. Genetic distances across a1-sh2 varied twofold among genetic backgrounds. Although the existence of regions exhibiting high and low rates of recombination (hot and cold spots, respectively) was conserved across backgrounds, the absolute rates of recombination in these sequence-identical regions differed significantly among backgrounds. In addition, an intergenic hot spot had a higher rate of recombination as compared to the genome average rate of recombination in one background and not in another. Recombination rates across two genetic intervals on chromosome 1 did not exhibit the same relationships among backgrounds as was observed in a1-sh2. This suggests that at least some detected trans-acting factors do not equally affect recombination across the genome. This study establishes that trans modifier(s) polymorphic among genetic backgrounds can increase and decrease recombination in both genic and intergenic regions over relatively small genetic and physical intervals.

MeSH Terms
Chromosomal Instability Chromosome Breakage Chromosome Mapping Chromosomes, Plant Crosses, Genetic DNA, Intergenic/drug effects Genetic Markers Genome, Plant Meiosis/drug effects Recombination, Genetic/drug effects Synteny Trans-Activators/pharmacology Zea mays/genetics
Chemicals
DNA, Intergenic Genetic Markers Trans-Activators
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yandeau-Nelson Marna D
Interdepartmental Genetics Program, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50014-3467, USA.
Nikolau Basil J
Schnable Patrick S
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.105.049270
Published
2006-09-00
Epub
2006-00-02
Pages
101-12
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1569796
Subset
IM
External Links
PubMed source DOI: 10.1534/genetics.105.049270 PMC Full Text View journal details
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