Home LiteratureArticle Details
PMID: 16822968 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

mRNA transport in dendrites: RNA granules, motors, and tracks.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 26 ·No. 27 ·2006-07-05 ·Pages 7139-42

Hirokawa N

Abstract

The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism. Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin superfamily protein KIF5 transports mRNAs such as calcium/calmodulin-dependent kinase IIalpha (CaMKIIalpha) and Arc mRNAs along microtubules in large granules containing proteins involved in RNA transport, protein synthesis, RNA helicases, heterogeneous nuclear ribonucleoproteins (hnRNPs), and RNA-associated proteins. This transport is fundamental to local protein synthesis and to the regulation of neuronal function.

MeSH Terms
Animals Cytoplasmic Granules/metabolism Dendrites/metabolism,ultrastructure Humans Molecular Motor Proteins/physiology RNA Transport/physiology RNA, Messenger/metabolism
Chemicals
Molecular Motor Proteins RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hirokawa Nobutaka
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo 113-0033, Japan. [email protected]
References (31)
31 references, click to expand
  1. Identification of a cis-acting dendritic targeting element in MAP2 mRNAs.
    J Neurosci. 1999 Oct 15;19(20):8818-29 PMID: 10516301
  2. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
    Science. 2000 May 19;288(5469):1254-7 PMID: 10818003
  3. A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein.
    Science. 2000 Sep 22;289(5487):2120-2 PMID: 11000113
  4. Localization of mRNAs at synaptic sites on dendrites.
    Results Probl Cell Differ. 2001;34:1-26 PMID: 11288670
  5. Identification of a cis-acting dendritic targeting element in the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II.
    Eur J Neurosci. 2001 May;13(10):1881-8 PMID: 11403681
  6. Neurotrophin-induced transport of a beta-actin mRNP complex increases beta-actin levels and stimulates growth cone motility.
    Neuron. 2001 Aug 2;31(2):261-75 PMID: 11502257
  7. Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis.
    Development. 2001 Sep;128(17):3233-42 PMID: 11546740
  8. The balance of power in RNA trafficking.
    Curr Opin Neurobiol. 2001 Oct;11(5):558-63 PMID: 11595488
  9. Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.
    Neuron. 2001 Nov 20;32(4):683-96 PMID: 11719208
  10. Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor.
    J Biol Chem. 2002 Oct 4;277(40):37804-10 PMID: 12147688
  11. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice.
    Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14500-5 PMID: 12391294
  12. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons.
    J Neurosci. 2003 Jan 1;23(1):131-40 PMID: 12514209
  13. Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain.
    Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2100-5 PMID: 12592035
  14. Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.
    J Cell Biol. 2003 Sep 15;162(6):1045-55 PMID: 12975348
  15. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
    Nucleic Acids Res. 2004 Apr 30;32(8):2411-20 PMID: 15121898
  16. Characterization of Staufen 1 ribonucleoprotein complexes.
    Biochem J. 2004 Dec 1;384(Pt 2):239-46 PMID: 15303970
  17. Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.
    Neuron. 2004 Aug 19;43(4):513-25 PMID: 15312650
  18. An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites.
    J Biol Chem. 2004 Dec 17;279(51):53427-34 PMID: 15475564
  19. Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.
    Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17428-33 PMID: 15583137
  20. Molecular motors and mechanisms of directional transport in neurons.
    Nat Rev Neurosci. 2005 Mar;6(3):201-14 PMID: 15711600
  21. The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
    Curr Biol. 2005 Mar 29;15(6):587-93 PMID: 15797031
  22. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.
    Nat Cell Biol. 2005 May;7(5):474-82 PMID: 15834408
  23. RNA trafficking and local protein synthesis in dendrites: an overview.
    J Neurosci. 2006 Jul 5;26(27):7131-4 PMID: 16822966
  24. RNA-binding proteins: a lesson in repression.
    J Neurosci. 2006 Jul 5;26(27):7135-8 PMID: 16822967
  25. Synaptic regulation of translation of dendritic mRNAs.
    J Neurosci. 2006 Jul 5;26(27):7143-6 PMID: 16822969
  26. Current advances in local protein synthesis and synaptic plasticity.
    J Neurosci. 2006 Jul 5;26(27):7147-50 PMID: 16822970
  27. Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond.
    J Neurosci. 2006 Jul 5;26(27):7151-5 PMID: 16822971
  28. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.
    Neuron. 1995 Feb;14(2):433-45 PMID: 7857651
  29. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity.
    Science. 1996 Sep 6;273(5280):1402-6 PMID: 8703078
  30. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.
    J Neurosci. 1998 Jan 1;18(1):251-65 PMID: 9412505
  31. Kinesin and dynein superfamily proteins and the mechanism of organelle transport.
    Science. 1998 Jan 23;279(5350):519-26 PMID: 9438838
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.1821-06.2006
Email
[email protected]
Published
2006-07-05
Pages
7139-42
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6673940
Subset
IM
External Links
PubMed source DOI: 10.1523/JNEUROSCI.1821-06.2006 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2