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PMID: 16824016 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.

Annual review of cell and developmental biology ·Vol. 22 ·2006-00-00 ·Pages 287-309

Nelson CM, Bissell MJ

Abstract

The microenvironment influences gene expression so that the behavior of a cell is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble local and systemic cues. We describe the essential roles of context and organ structure in directing mammary gland development and differentiated function and in determining the response to oncogenic insults, including mutations. We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music.

MeSH Terms
Breast Neoplasms/pathology Extracellular Matrix/metabolism Homeostasis Humans Mammary Glands, Human/cytology Organ Specificity Signal Transduction
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nelson Celeste M
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. [email protected]
Bissell Mina J
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Article Info
Journal
Annual review of cell and developmental biology
Abbr.
Annu Rev Cell Dev Biol
ISSN
1081-0706
DOI
10.1146/annurev.cellbio.22.010305.104315
Email
[email protected]
Published
2006-00-00
Pages
287-309
Language
English
Region
United States
NLM ID
9600627
PMCID
PMC2933192
Subset
IM
Grants
NCI NIH HHS · R37 CA064786 · United States
NCI NIH HHS · R01 CA064786-06 · United States
NCI NIH HHS · R01 CA057621 · United States
NCI NIH HHS · CA64786 · United States
NCI NIH HHS · CA57621 · United States
NCI NIH HHS · R01 CA057621-07 · United States
NCI NIH HHS · R01 CA064786 · United States
External Links
PubMed source DOI: 10.1146/annurev.cellbio.22.010305.104315 PMC Full Text View journal details
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