Modulation of MHC antigen expression by viruses and oncogenes.

Immunology today ·Vol. 12 ·No. 12 ·1991-12-00 ·Pages 429-31

Maudsley DJ, Pound JD

Abstract

It is becoming increasingly clear that regulation of MHC antigen expression by viruses and oncogenes, leading to either immune evasion or autoimmunity, is widespread and important in disease. At a recent meeting*, which brought together workers interested in tumour immunology, viral infection and the MHC, a number of mechanisms for the regulation of MHC antigen expression were revealed and the importance of balanced expression of MHC gene products to effective immunity was underlined.

Related Genes

E1a c-myc myc v-Ki-ras

MeSH Terms

Animals Antigens, Neoplasm/biosynthesis,genetics Cell Adhesion Molecules/biosynthesis,genetics Cell Transformation, Neoplastic/genetics Cell Transformation, Viral Cytokines/physiology Gene Expression Regulation Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral HLA Antigens/biosynthesis,genetics Histocompatibility Antigens/biosynthesis,genetics Humans Major Histocompatibility Complex Oncogenes Oncogenic Viruses/genetics,physiology Virus Diseases/immunology Virus Physiological Phenomena Viruses/genetics

Chemicals

Antigens, Neoplasm Cell Adhesion Molecules Cytokines HLA Antigens Histocompatibility Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Maudsley D J

Dept of Biological Sciences, University of Warwick, Coventry, UK.

Pound J D

References (24)

24 references, click to expand

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Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(91)90013-J

Published

1991-12-00

Pages

429-31

Language

English

Region

England

NLM ID

8008346

PMCID

PMC7173125

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(91)90013-J PMC Full Text

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Modulation of MHC antigen expression by viruses and oncogenes.

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