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PMID: 16865768 Published · ppublish English Journal Article Review

Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility.

World journal of gastroenterology ·Vol. 12 ·No. 27 ·2006-07-21 ·Pages 4281-95

Oates PS, West AR

Abstract

The gastrointestinal tract is lined by a simple epithelium that undergoes constant renewal involving cell division, differentiation and cell death. In addition, the epithelial lining separates the hostile processes of digestion and absorption that occur in the intestinal lumen from the aseptic environment of the internal milieu by defensive mechanisms that protect the epithelium from being breached. Central to these defensive processes is the synthesis of heme and its catabolism by heme oxygenase (HO). Dietary heme is also an important source of iron for the body which is taken up intact by the enterocyte. This review describes the recent literature on the diverse properties of heme/HO in the intestine tract. The roles of heme/HO in the regulation of the cell cycle/apoptosis, detoxification of xenobiotics, oxidative stress, inflammation, development of colon cancer, heme-iron absorption and intestinal motility are specifically examined.

MeSH Terms
Animals Cell Cycle/physiology Cell Differentiation/physiology Colonic Neoplasms/pathology,physiopathology Gastrointestinal Motility/physiology Heme/biosynthesis,physiology Heme Oxygenase (Decyclizing)/physiology Humans Inactivation, Metabolic/physiology Inflammation/pathology,physiopathology Intestinal Absorption/physiology Intestinal Mucosa/cytology,pathology,physiology,physiopathology Iron/metabolism
Chemicals
Heme Iron Heme Oxygenase (Decyclizing)
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oates Phillip-S
West Adrian-R
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v12.i27.4281
Published
2006-07-21
Pages
4281-95
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4087737
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v12.i27.4281 PMC Full Text View journal details
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