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PMID: 16919437 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

CEACAMs: their role in physiology and pathophysiology.

Current opinion in cell biology ·Vol. 18 ·No. 5 ·2006-10-00 ·Pages 565-71

Kuespert K, Pils S, Hauck CR

Abstract

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo.

MeSH Terms
Animals Animals, Genetically Modified Antigens, CD/genetics,metabolism Bacteria/pathogenicity Carcinoembryonic Antigen/metabolism Cell Adhesion Molecules/genetics,metabolism Evolution, Molecular Humans Insulin/metabolism Neoplasms/metabolism,pathology Neovascularization, Physiologic Protein Isoforms/genetics,metabolism Viruses/pathogenicity
Chemicals
Antigens, CD CD66 antigens CEACAM3 protein, human Carcinoembryonic Antigen Cell Adhesion Molecules Insulin Protein Isoforms
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kuespert Katharina
Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
Pils Stefan
Hauck Christof R
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2006.08.008
Published
2006-10-00
Epub
2006-00-17
Pages
565-71
Language
English
Region
England
NLM ID
8913428
PMCID
PMC7127089
Subset
IM
External Links
PubMed source DOI: 10.1016/j.ceb.2006.08.008 PMC Full Text View journal details
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