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PMID: 16920658 Published · ppublish English Corrected and Republished Article Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Biomarkers to assess the utility of potential reduced exposure tobacco products.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco ·Vol. 8 ·No. 4 ·2006-08-00 ·Pages 600-22

Hatsukami DK, Benowitz NL, Rennard SI, Oncken C, Hecht SS

Abstract

To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.

MeSH Terms
Biomarkers/metabolism Carcinogens/analysis Cardiovascular Diseases/physiopathology Fetus/drug effects Humans Lung Diseases/physiopathology Neoplasms/physiopathology Respiratory Function Tests Sensitivity and Specificity Smoking/adverse effects Tobacco/adverse effects,metabolism,toxicity
Chemicals
Biomarkers Carcinogens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hatsukami Dorothy K
University of Minnesota Cancer Center, Minneapolis, MN, USA. [email protected]
Benowitz Neal L
Rennard Stephen I
Oncken Cheryl
Hecht Stephen S
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Article Info
Journal
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Abbr.
Nicotine Tob Res
ISSN
1462-2203
DOI
10.1080/14622200600858166
Email
[email protected]
Published
2006-08-00
Pages
600-22
Language
English
Region
England
NLM ID
9815751
PMCID
PMC6615727
Subset
IM
Grants
NIDA NIH HHS · R01 DA015167 · United States
NIDA NIH HHS · P50 DA013333 · United States
NIDA NIH HHS · DA013333 · United States
Wellcome Trust · DA15167 · United Kingdom
NIDA NIH HHS · DA0227 · United States
Corrections
RepublishedFrom
PMID: 16766411
External Links
PubMed source DOI: 10.1080/14622200600858166 PMC Full Text View journal details
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