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PMID: 1693430 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Evolutionary origin of human and simian immunodeficiency viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 11 ·1990-06-00 ·Pages 4108-11

Gojobori T, Moriyama EN, Ina Y, Ikeo K, Miura T, Tsujimoto H, Hayami M, Yokoyama S

Abstract

From what viruses the human immunodeficiency viruses (HIVs) originated is an extremely controversial question. To address this question, we have analyzed nucleotide sequences of simian immunodeficiency viruses (SIVs) and HIVs by using the techniques for understanding molecular evolution. In particular, we compared the nucleotide sequences of whole genomes, gene region by gene region, between a given pair of viruses, including four types of SIVs--isolated from mandrills (Papio sphinx), African green monkeys (Cercopithecus aethiops), sooty mangabeys (Cercocebus atys), and rhesus macaques (Macaca mulatta)--as well as HIVs. Phylogenetic trees for all gene regions examined showed that the present HIVs may have emerged as different variants of SIVs of Old World monkeys, possibly from recombination between viruses related to SIVs.

MeSH Terms
Biological Evolution Endonucleases/genetics Genes, Viral HIV/genetics Phylogeny RNA-Directed DNA Polymerase/genetics Retroviridae/genetics Retroviridae Proteins/genetics Simian Immunodeficiency Virus/genetics Viral Structural Proteins/genetics
Chemicals
Retroviridae Proteins Viral Structural Proteins RNA-Directed DNA Polymerase Endonucleases
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Gojobori T
National Institute of Genetics, Mishima, Japan.
Moriyama E N
Ina Y
Ikeo K
Miura T
Tsujimoto H
Hayami M
Yokoyama S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.11.4108
Published
1990-06-00
Pages
4108-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC54056
Subset
IM
Grants
NIGMS NIH HHS · GM-28672 · United States
NIGMS NIH HHS · GM-4237 · United States
External Links
PubMed source DOI: 10.1073/pnas.87.11.4108 PMC Full Text View journal details
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