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PMID: 16950986 Published · ppublish English Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural

A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children.

Pediatrics ·Vol. 118 ·No. 3 ·2006-09-00 ·Pages 961-70

Ment LR, Peterson BS, Meltzer JA, Vohr B, Allan W, Katz KH, Lacadie C, Schneider KC, Duncan CC, Makuch RW, Constable RT

Abstract

Previous studies have demonstrated that indomethacin lowers the incidence and decreases the severity of intraventricular hemorrhage, as well as improves the cognitive outcome, in prematurely born male infants. The purpose of this work was to use functional magnetic resonance imaging to test the hypothesis that neonatal indomethacin treatment would differentially affect brain activation across genders in school-aged, prematurely born children during performance of a language task. Forty-seven prematurely born children (600-1250-g birth weight) and 24 matched term control subjects were evaluated using a functional magnetic resonance imaging passive language task and neurodevelopmental assessments that included the Wechsler Intelligence Scale for Children-III and the Peabody Picture Vocabulary Test-Revised. Neural activity was assessed during both phonologic and semantic processing in the functional magnetic resonance imaging protocol. Neurodevelopmental assessments demonstrated significant differences in full-scale, verbal, and performance intelligence quotient, as well as Peabody Picture Vocabulary Test scores, between the preterm and term control subjects. Rates of perinatal complications did not differ significantly across preterm treatment groups, but male preterm subjects randomly assigned to saline tended to have lower Peabody Picture Vocabulary Test-Revised scores than did all of the other preterm groups. During phonological processing, a significant treatment-by-gender effect was demonstrated in 3 brain regions: the left inferior parietal lobule, the left inferior frontal gyrus (Broca's area), and the right dorsolateral prefrontal cortex. These data demonstrate a differential effect of indomethacin administration early in postnatal life on the subsequent development of neural systems that subserve language functioning in these male and female preterm infants.

MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Brain/drug effects,growth & development,physiology Child Cognition Disorders/etiology,prevention & control Cohort Studies Female Humans Indomethacin/therapeutic use Infant Infant, Newborn Infant, Premature Language Magnetic Resonance Imaging Male
Chemicals
Anti-Inflammatory Agents, Non-Steroidal Indomethacin
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Ment Laura R
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA. [email protected]
Peterson Bradley S
Meltzer Jed A
Vohr Betty
Allan Walter
Katz Karol H
Lacadie Cheryl
Schneider Karen C
Duncan Charles C
Makuch Robert W
Constable R Todd
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Article Info
Journal
Pediatrics
Abbr.
Pediatrics
ISSN
1098-4275
DOI
10.1542/peds.2005-2870
Email
[email protected]
Published
2006-09-00
Pages
961-70
Language
English
Region
United States
NLM ID
0376422
PMCID
PMC2364718
Subset
IM
Grants
NIMH NIH HHS · R01 MH068318-03 · United States
NIDA NIH HHS · R01 DA017820 · United States
NINDS NIH HHS · R01 NS038467 · United States
NIDA NIH HHS · R01 DA017820-03 · United States
NIDA NIH HHS · DA017820 · United States
NINDS NIH HHS · R01 NS027116 · United States
NCRR NIH HHS · MO1-RR06022 · United States
NIBIB NIH HHS · R01 EB000473 · United States
NINDS NIH HHS · NS 27116 · United States
PHS HHS · K02-74677 · United States
NIMH NIH HHS · K02 MH074677 · United States
NINDS NIH HHS · NS38467 · United States
NIMH NIH HHS · K02 MH074677-01 · United States
NINDS NIH HHS · P01 NS035476 · United States
NIMH NIH HHS · R01 MH068318 · United States
NCRR NIH HHS · MO1-RR00125 · United States
NIBIB NIH HHS · EB00473 · United States
NINDS NIH HHS · NS 35476 · United States
NCRR NIH HHS · M01 RR000125 · United States
NCRR NIH HHS · M01 RR006022 · United States
External Links
PubMed source DOI: 10.1542/peds.2005-2870 PMC Full Text View journal details
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