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PMID: 16998613 Published · ppublish English Journal Article Review

Periodontal disease and systemic conditions: a bidirectional relationship.

Odontology ·Vol. 94 ·No. 1 ·2006-09-00 ·Pages 10-21

Kim J, Amar S

Abstract

For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.

MeSH Terms
C-Reactive Protein/physiology Cardiovascular Diseases/complications,metabolism,microbiology Diabetes Complications/metabolism,microbiology Female Humans Infant, Low Birth Weight Infant, Newborn Inflammation Mediators/metabolism Nitric Oxide/metabolism Osteoporosis/complications,metabolism Periodontal Diseases/complications,microbiology Pregnancy Premature Birth/etiology,microbiology
Chemicals
Inflammation Mediators Nitric Oxide C-Reactive Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kim Jemin
Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA, USA.
Amar Salomon
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Article Info
Journal
Odontology
Abbr.
Odontology
ISSN
1618-1247
DOI
10.1007/s10266-006-0060-6
Published
2006-09-00
Pages
10-21
Language
English
Region
Japan
NLM ID
101134822
PMCID
PMC2443711
Subset
IM
Grants
NHLBI NIH HHS · R01 HL076801 · United States
NHLBI NIH HHS · R01 HL076801-01A1 · United States
NHLBI NIH HHS · R01 HL076801-02 · United States
External Links
PubMed source DOI: 10.1007/s10266-006-0060-6 PMC Full Text View journal details
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