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PMID: 17095691 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

The genome of the sea urchin Strongylocentrotus purpuratus.

Science (New York, N.Y.) ·Vol. 314 ·No. 5801 ·2006-11-10 ·Pages 941-52

Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R

Abstract

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

MeSH Terms
Animals Calcification, Physiologic Cell Adhesion Molecules/genetics,physiology Complement Activation/genetics Computational Biology Embryonic Development/genetics Evolution, Molecular Gene Expression Regulation, Developmental Genes Genome Immunity, Innate/genetics Immunologic Factors/genetics,physiology Male Nervous System Physiological Phenomena Proteins/genetics,physiology Sequence Analysis, DNA Signal Transduction Strongylocentrotus purpuratus/embryology,genetics,immunology,physiology Transcription Factors/genetics
Chemicals
Cell Adhesion Molecules Immunologic Factors Proteins Transcription Factors
Authors & Affiliations
229 authors, click to expand affiliations / ORCID
Sea Urchin Genome Sequencing Consortium
Sodergren Erica
Weinstock George M
Davidson Eric H
Cameron R Andrew
Gibbs Richard A
Angerer Robert C
Angerer Lynne M
Arnone Maria Ina
Burgess David R
Burke Robert D
Coffman James A
Dean Michael
Elphick Maurice R
Ettensohn Charles A
Foltz Kathy R
Hamdoun Amro
Hynes Richard O
Klein William H
Marzluff William
McClay David R
Morris Robert L
Mushegian Arcady
Rast Jonathan P
Smith L Courtney
Thorndyke Michael C
Vacquier Victor D
Wessel Gary M
Wray Greg
Zhang Lan
Elsik Christine G
Ermolaeva Olga
Hlavina Wratko
Hofmann Gretchen
Kitts Paul
Landrum Melissa J
Mackey Aaron J
Maglott Donna
Panopoulou Georgia
Poustka Albert J
Pruitt Kim
Sapojnikov Victor
Song Xingzhi
Souvorov Alexandre
Solovyev Victor
Wei Zheng
Whittaker Charles A
Worley Kim
Durbin K James
Shen Yufeng
Fedrigo Olivier
Garfield David
Haygood Ralph
Primus Alexander
Satija Rahul
Severson Tonya
Gonzalez-Garay Manuel L
Jackson Andrew R
Milosavljevic Aleksandar
Tong Mark
Killian Christopher E
Livingston Brian T
Wilt Fred H
Adams Nikki
Bellé Robert
Carbonneau Seth
Cheung Rocky
Cormier Patrick
Cosson Bertrand
Croce Jenifer
Fernandez-Guerra Antonio
Genevière Anne-Marie
Goel Manisha
Kelkar Hemant
Morales Julia
Mulner-Lorillon Odile
Robertson Anthony J
Goldstone Jared V
Cole Bryan
Epel David
Gold Bert
Hahn Mark E
Howard-Ashby Meredith
Scally Mark
Stegeman John J
Allgood Erin L
Cool Jonah
Judkins Kyle M
McCafferty Shawn S
Musante Ashlan M
Obar Robert A
Rawson Amanda P
Rossetti Blair J
Gibbons Ian R
Hoffman Matthew P
Leone Andrew
Istrail Sorin
Materna Stefan C
Samanta Manoj P
Stolc Viktor
Tongprasit Waraporn
Tu Qiang
Bergeron Karl-Frederik
Brandhorst Bruce P
Whittle James
Berney Kevin
Bottjer David J
Calestani Cristina
Peterson Kevin
Chow Elly
Yuan Qiu Autumn
Elhaik Eran
Graur Dan
Reese Justin T
Bosdet Ian
Heesun Shin
Marra Marco A
Schein Jacqueline
Anderson Michele K
Brockton Virginia
Buckley Katherine M
Cohen Avis H
Fugmann Sebastian D
Hibino Taku
Loza-Coll Mariano
Majeske Audrey J
Messier Cynthia
Nair Sham V
Pancer Zeev
Terwilliger David P
Agca Cavit
Arboleda Enrique
Chen Nansheng
Churcher Allison M
Hallböök F
Humphrey Glen W
Idris Mohammed M
Kiyama Takae
Liang Shuguang
Mellott Dan
Mu Xiuqian
Murray Greg
Olinski Robert P
Raible Florian
Rowe Matthew
Taylor John S
Tessmar-Raible Kristin
Wang D
Wilson Karen H
Yaguchi Shunsuke
Gaasterland Terry
Galindo Blanca E
Gunaratne Herath J
Juliano Celina
Kinukawa Masashi
Moy Gary W
Neill Anna T
Nomura Mamoru
Raisch Michael
Reade Anna
Roux Michelle M
Song Jia L
Su Yi-Hsien
Townley Ian K
Voronina Ekaterina
Wong Julian L
Amore Gabriele
Branno Margherita
Brown Euan R
Cavalieri Vincenzo
Duboc Véronique
Duloquin Louise
Flytzanis Constantin
Gache Christian
Lapraz François
Lepage Thierry
Locascio Annamaria
Martinez Pedro
Matassi Giorgio
Matranga Valeria
Range Ryan
Rizzo Francesca
Röttinger Eric
Beane Wendy
Bradham Cynthia
Byrum Christine
Glenn Tom
Hussain Sofia
Manning Gerard
Miranda Esther
Thomason Rebecca
Walton Katherine
Wikramanayke Athula
Wu Shu-Yu
Xu Ronghui
Brown C Titus
Chen Lili
Gray Rachel F
Lee Pei Yun
Nam Jongmin
Oliveri Paola
Smith Joel
Muzny Donna
Bell Stephanie
Chacko Joseph
Cree Andrew
Curry Stacey
Davis Clay
Dinh Huyen
Dugan-Rocha Shannon
Fowler Jerry
Gill Rachel
Hamilton Cerrissa
Hernandez Judith
Hines Sandra
Hume Jennifer
Jackson Laronda
Jolivet Angela
Kovar Christie
Lee Sandra
Lewis Lora
Miner George
Morgan Margaret
Nazareth Lynne V
Okwuonu Geoffrey
Parker David
Pu Ling-Ling
Thorn Rachel
Wright Rita
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2006-11-10
Pages
941-52
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3159423
Subset
IM
Grants
NIEHS NIH HHS · P42 ES007381 · United States
NICHD NIH HHS · R37-HD12896 · United States
NIGMS NIH HHS · GM058231 · United States
NICHD NIH HHS · P01 HD037105 · United States
PHS HHS · 2P42 ESO7381 · United States
NICHD NIH HHS · F32 HD047136 · United States
NICHD NIH HHS · F32 HD047136-03 · United States
NIGMS NIH HHS · GM61005 · United States
NIEHS NIH HHS · R01 ES006272 · United States
NIGMS NIH HHS · T32 GM007601 · United States
NICHD NIH HHS · P01 HD039948 · United States
Biotechnology and Biological Sciences Research Council · S19916 · United Kingdom
NIH HHS · P40 OD010959 · United States
NIGMS NIH HHS · R01 GM061005 · United States
NCI NIH HHS · P30 CA014051 · United States
NCI NIH HHS · R43 CA093106 · United States
NIGMS NIH HHS · R01 GM070840 · United States
NIGMS NIH HHS · GM61464 · United States
NHGRI NIH HHS · U54 HG003273 · United States
NCI NIH HHS · P30-CA14051 · United States
NIEHS NIH HHS · F32 ES012794 · United States
NEI NIH HHS · EY11930 · United States
NICHD NIH HHS · R01 HD028152 · United States
NEI NIH HHS · R01 EY011930 · United States
PHS HHS · F32 ESO12794 · United States
NCRR NIH HHS · RR-15044 · United States
NICHD NIH HHS · R01 HD014483 · United States
NIGMS NIH HHS · R01 GM058231 · United States
NICHD NIH HHS · HD14483 · United States
NICHD NIH HHS · HD039948 · United States
NICHD NIH HHS · HD66219 · United States
NICHD NIH HHS · F32-HD47136 · United States
NCI NIH HHS · R44 CA093106 · United States
NIEHS NIH HHS · R01ES006272 · United States
NHGRI NIH HHS · 5 U54 HG003273 · United States
NICHD NIH HHS · F32 HD047136-02 · United States
NCRR NIH HHS · P40 RR015044 · United States
NIGMS NIH HHS · GM070840 · United States
NICHD NIH HHS · HD-37105 · United States
NIEHS NIH HHS · R01 ES006272-13 · United States
NICHD NIH HHS · R01 HD066219 · United States
NIGMS NIH HHS · R01 GM061464 · United States
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