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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Diabetes. 2003 Feb;52(2):568-72
PMID: 12540637
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Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization.
Best Pract Res Clin Endocrinol Metab. 2001 Sep;15(3):309-23
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Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.
Am J Hum Genet. 2003 Aug;73(2):323-35
PMID: 12851856
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Revisiting the clinical validity of multiplex genetic testing in complex diseases.
Am J Hum Genet. 2004 Mar;74(3):585-8; author reply 588-9
PMID: 14973786
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Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification.
Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R33-41
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Can twin studies assess the genetic component in type 2 (non-insulin-dependent) diabetes mellitus?
Diabetologia. 1993 May;36(5):471-2
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Genome-wide association studies: theoretical and practical concerns.
Nat Rev Genet. 2005 Feb;6(2):109-18
PMID: 15716907
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Making the right associations.
Diabetologia. 2005 Jul;48(7):1241-3
PMID: 15918013
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How many genes underlie the occurrence of common complex diseases in the population?
Int J Epidemiol. 2005 Oct;34(5):1129-37
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What makes a good genetic association study?
Lancet. 2005 Oct 8;366(9493):1315-23
PMID: 16214603
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Nat Genet. 2006 Mar;38(3):320-3
PMID: 16415884
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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
N Engl J Med. 2006 Jul 20;355(3):241-50
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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
N Engl J Med. 2006 Aug 3;355(5):467-77
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Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Diabetes. 2006 Sep;55(9):2640-4
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Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.
Diabetes. 2006 Sep;55(9):2645-8
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Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
Diabetes. 2006 Sep;55(9):2649-53
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Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
Diabetes. 2006 Sep;55(9):2654-9
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Predictive genetic testing for type 2 diabetes.
BMJ. 2006 Sep 9;333(7567):509-10
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Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Diabetes. 2006 Oct;55(10):2890-5
PMID: 17003358
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Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Diabetes. 2006 Oct;55(10):2903-8
PMID: 17003360
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
PLoS Med. 2006 Oct;3(10):e374
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Will genetics revolutionize medicine?
N Engl J Med. 2000 Jul 13;343(2):141-4
PMID: 10891526
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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.
Nat Genet. 2000 Sep;26(1):76-80
PMID: 10973253
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A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
Am J Hum Genet. 2001 Sep;69(3):553-69
PMID: 11484155
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The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes.
Diabetologia. 2001 Jul;44(7):914-22
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The double helix in clinical practice.
Nature. 2003 Jan 23;421(6921):414-6
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Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
Diabetologia. 2007 Jan;50(1):63-7
PMID: 17093941
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Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
Diabetologia. 2007 Jan;50(1):59-62
PMID: 17031610
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Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.
Diabetologia. 2007 Jan;50(1):212-3
PMID: 17063324
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No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects.
Diabetologia. 2007 Jan;50(1):214-6
PMID: 17093940