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PMID: 17114581 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Variation in the epigenetic silencing of FLC contributes to natural variation in Arabidopsis vernalization response.

Genes & development ·Vol. 20 ·No. 22 ·2006-11-15 ·Pages 3079-83

Shindo C, Lister C, Crevillen P, Nordborg M, Dean C

Abstract

Vernalization, the cold-induced acceleration of flowering, involves the epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC). We investigated the molecular basis for variation in vernalization in Arabidopsis natural accessions adapted to different climates. A major variable was the degree to which different periods of cold caused stable FLC silencing. In accessions requiring long vernalization, FLC expression was reactivated following nonsaturating vernalization, but this reactivation was progressively attenuated with increasing cold exposure. This response was correlated with the rate of accumulation of FLC histone H3 Lys 27 trimethylation (H3K27me3). Thus, variation in epigenetic silencing of FLC appears to have contributed to Arabidopsis adaptation.

MeSH Terms
Alleles Arabidopsis/genetics,physiology Arabidopsis Proteins/genetics,metabolism Chromatin/metabolism Chromatin Immunoprecipitation Cold Temperature Epigenesis, Genetic Flowers/physiology Gene Expression Regulation, Plant Gene Silencing Genes, Plant Genetic Variation MADS Domain Proteins/genetics,metabolism Models, Genetic Phenotype Quantitative Trait Loci/genetics RNA, Messenger/genetics,metabolism Repressor Proteins/metabolism
Chemicals
Arabidopsis Proteins Chromatin FLF protein, Arabidopsis MADS Domain Proteins RNA, Messenger Repressor Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Shindo Chikako
Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom.
Lister Clare
Crevillen Pedro
Nordborg Magnus
Dean Caroline
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.405306
Published
2006-11-15
Pages
3079-83
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC1635143
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BBS/E/J/00000581 · United Kingdom
External Links
PubMed source DOI: 10.1101/gad.405306 PMC Full Text View journal details
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