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PMID: 17114938 Published · ppublish English Journal Article Review

A-to-I RNA editing and human disease.

RNA biology ·Vol. 3 ·No. 1 ·2006-00-00 ·Pages 1-9

Maas S, Kawahara Y, Tamburro KM, Nishikura K

Abstract

The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information. As the molecular players of editing are characterized and an increasing number of genes become identified that are subject to A-to-I modification, the potential impact of editing on the etiology or progression of human diseases is realized. Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes.

MeSH Terms
Adenosine/chemistry,genetics Amino Acid Sequence Amyotrophic Lateral Sclerosis/genetics Animals Epilepsy/genetics Humans Inosine/chemistry,genetics Measles/genetics Mice Models, Genetic Molecular Sequence Data Mutation RNA Editing/genetics RNA Processing, Post-Transcriptional Skin Diseases/genetics
Chemicals
Inosine Adenosine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Maas Stefan
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA. [email protected] <[email protected]>
Kawahara Yukio
Tamburro Kristen M
Nishikura Kazuko
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Article Info
Journal
RNA biology
Abbr.
RNA Biol
ISSN
1555-8584
DOI
10.4161/rna.3.1.2495
Email
[email protected]
Published
2006-00-00
Epub
2006-00-12
Pages
1-9
Language
English
Region
United States
NLM ID
101235328
PMCID
PMC2947206
Subset
IM
Grants
NCI NIH HHS · P01 CA072765-040002 · United States
NIGMS NIH HHS · R01 GM040536 · United States
NHLBI NIH HHS · R01 HL070045 · United States
NIGMS NIH HHS · R01 GM040536-16 · United States
NCI NIH HHS · P01 CA072765 · United States
NHLBI NIH HHS · R01 HL070045-04 · United States
External Links
PubMed source DOI: 10.4161/rna.3.1.2495 PMC Full Text View journal details
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