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PMID: 17116700 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.

Pediatrics ·Vol. 118 ·No. 6 ·2006-12-00 ·Pages e1845-59

Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, Whitehead R, Tang D, Whyatt RW

Abstract

The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal exposure to chlorpyrifos were evaluated in 254 children through the first 3 years of life. This report examined cognitive and motor development at 12, 24, and 36 months (measured with the Bayley Scales of Infant Development II) and child behavior at 36 months (measured with the Child Behavior Checklist) as a function of chlorpyrifos levels in umbilical cord plasma. Highly exposed children (chlorpyrifos levels of >6.17 pg/g plasma) scored, on average, 6.5 points lower on the Bayley Psychomotor Development Index and 3.3 points lower on the Bayley Mental Development Index at 3 years of age compared with those with lower levels of exposure. Children exposed to higher, compared with lower, chlorpyrifos levels were also significantly more likely to experience Psychomotor Development Index and Mental Development Index delays, attention problems, attention-deficit/hyperactivity disorder problems, and pervasive developmental disorder problems at 3 years of age. The adjusted mean 36-month Psychomotor Development Index and Mental Development Index scores of the highly and lower exposed groups differed by only 7.1 and 3.0 points, respectively, but the proportion of delayed children in the high-exposure group, compared with the low-exposure group, was 5 times greater for the Psychomotor Development Index and 2.4 times greater for the Mental Development Index, increasing the number of children possibly needing early intervention services.

MeSH Terms
Adult Child, Preschool Chlorpyrifos/adverse effects Cognition/drug effects Female Humans Infant Insecticides/adverse effects Male Motor Skills/drug effects Nervous System/drug effects,growth & development Pregnancy Prenatal Exposure Delayed Effects/etiology Time Factors Urban Population
Chemicals
Insecticides Chlorpyrifos
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Rauh Virginia A
Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Ave, B-109, New York, NY 10032, USA. [email protected]
Garfinkel Robin
Perera Frederica P
Andrews Howard F
Hoepner Lori
Barr Dana B
Whitehead Ralph
Tang Deliang
Whyatt Robin W
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Article Info
Journal
Pediatrics
Abbr.
Pediatrics
ISSN
1098-4275
DOI
10.1542/peds.2006-0338
Email
[email protected]
Published
2006-12-00
Epub
2006-00-20
Pages
e1845-59
Language
English
Region
United States
NLM ID
0376422
PMCID
PMC3390915
Subset
IM
Grants
NIEHS NIH HHS · P01 ES009600 · United States
NCRR NIH HHS · M01 RR000645 · United States
NCRR NIH HHS · RR00645 · United States
NIEHS NIH HHS · R01 ES012468 · United States
NIEHS NIH HHS · R01 ES010165 · United States
NIEHS NIH HHS · 5 R01 ES008977 · United States
NIEHS NIH HHS · 5 R01ES11158 · United States
NIEHS NIH HHS · R01 ES011158 · United States
NIEHS NIH HHS · 5 P01 ES009600 · United States
NIEHS NIH HHS · R01 ES008977 · United States
NIEHS NIH HHS · 5 R01 ES10165 · United States
NIEHS NIH HHS · 5 R01 ES012468 · United States
Corrections
CommentIn
PMID: 17606590
External Links
PubMed source DOI: 10.1542/peds.2006-0338 PMC Full Text View journal details
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