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PMID: 171653 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 8 ·1975-08-00 ·Pages 3124-8

Newcombe DS, Ciosek CP, Ishikawa Y, Fahey JV

Abstract

The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.

MeSH Terms
3',5'-Cyclic-AMP Phosphodiesterases/metabolism Cells, Cultured Cyclic AMP/metabolism Enzyme Activation/drug effects Epinephrine/pharmacology Humans Prostaglandins E/pharmacology Synovial Membrane/cytology,drug effects,metabolism Tendons/cytology,drug effects,metabolism Theophylline/pharmacology
Chemicals
Prostaglandins E Theophylline Cyclic AMP 3',5'-Cyclic-AMP Phosphodiesterases Epinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Newcombe D S
Ciosek C P
Ishikawa Y
Fahey J V
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18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.8.3124
Published
1975-08-00
Pages
3124-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432933
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.8.3124 PMC Full Text View journal details
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