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PMID: 171672 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Relationship between A-type and C-type particles in cells infected by Rous sarcoma virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 9 ·1975-09-00 ·Pages 3706-10

de Giuli C, Hanafusa H, Kawai S, Dales S, Chen JH, Hsu KC

Abstract

Chicken cells infected with avian RNA tumor virus often contain small cytoplasmic A-type particles which commonly exist as clusters of 50--100 particles when viewed in thin sections. These particles were found more consistently in Rous sarcoma virus-infected than Rous-associated virus-infected cultures, but were generally present in only a small fraction of the total infected cells. The results of the survey of cells infected with various strains of leukosis-sarcoma viruses led to the hypothesis that the A particles develop in cells undergoing cytopathological degeneration. The hypothesis explains also the evanescent nature of the appearance of these particles in infected cells. The application of immunoelectron microscopic methods using monospecific antisera against viral internal proteins revealed that the A particles contain components immunologically related to the proteins of C-type virus.

MeSH Terms
Animals Antigens, Viral/analysis Avian Leukosis Virus/immunology,ultrastructure Avian Sarcoma Viruses/immunology,ultrastructure Chick Embryo Cytopathogenic Effect, Viral Inclusion Bodies, Viral Retroviridae/immunology,ultrastructure
Chemicals
Antigens, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
de Giuli C
Hanafusa H
Kawai S
Dales S
Chen J H
Hsu K C
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.9.3706
Published
1975-09-00
Pages
3706-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433066
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.9.3706 PMC Full Text View journal details
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