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PMID: 172450 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effect of pretreatment with Mycobacterium bovis (strain BCG) and immune syphilitic serum on rabbit resistance to Treponema pallidum.

Infection and immunity ·Vol. 12 ·No. 5 ·1975-11-00 ·Pages 1029-36

Graves SR, Johnson RC

Abstract

Stimulation of the rabbit reticuloendothelial system with viable Mycobacterium bovis (strain BCG), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of Treponema pallidum (virulent Nichol's strain; mean infective doses less than 10). The simultaneous administration of immune syphilitic rabbit serum retarded the development of lesions, but this appeared to be due solely to the immune serum, suggesting no synergism between the activated reticuloendothelial system and the anti-T. pallidum antibodies. The administration of two doses of BCG enhanced syphilitic lesion development in the rabbit.

MeSH Terms
Animals Antigens, Bacterial/administration & dosage BCG Vaccine Bordetella pertussis/immunology Immune Sera/pharmacology Injections, Intravenous Lipopolysaccharides/administration & dosage Male Mononuclear Phagocyte System/metabolism Mycobacterium bovis/immunology Propionibacterium acnes/immunology Rabbits Skin Tests Syphilis/immunology Time Factors Treponema pallidum/immunology
Chemicals
Antigens, Bacterial BCG Vaccine Immune Sera Lipopolysaccharides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Graves S R
Johnson R C
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32 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.12.5.1029-1036.1975
Published
1975-11-00
Pages
1029-36
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415393
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.12.5.1029-1036.1975 PMC Full Text View journal details
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