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PMID: 17251051 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The extracellular matrix as an adhesion checkpoint for mammary epithelial function.

The international journal of biochemistry & cell biology ·Vol. 39 ·No. 4 ·2007-00-00 ·Pages 715-26

Katz E, Streuli CH

Abstract

The development of the mammary gland is spatially regulated by the interaction of the mammary epithelium with the extracellular matrix (ECM). Cells receive cues from the ECM through a family of adhesion receptors called integrins, consisting of alpha- and beta-chain dimers. Integrins assist cells in sensing their appropriate developmental context in response to both hormones and growth factors. Here we argue that cell adhesion to the ECM plays a key role in specific developmental checkpoints, particularly in alveolar survival, morphogenesis and function. Specific ablation of alphabeta1-integrins in the luminal epithelium of the mammary gland shows that this sub-type of receptors is required for proliferation, accurate morphological organisation, as well as milk secretion. Downstream, small Rho GTPases mediate cellular polarisation and differentiation. Current challenges in studying the integration of signals in checkpoints of mammary gland development are discussed.

MeSH Terms
Animals Cell Adhesion/physiology Epithelial Cells/metabolism,physiology Extracellular Matrix/physiology Humans Mammary Glands, Animal/cytology,metabolism,physiology Mammary Glands, Human/cytology,metabolism,physiology Models, Biological Signal Transduction/physiology rho GTP-Binding Proteins/metabolism
Chemicals
rho GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Katz Elad
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Streuli Charles H
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Article Info
Journal
The international journal of biochemistry & cell biology
Abbr.
Int J Biochem Cell Biol
ISSN
1357-2725
DOI
10.1016/j.biocel.2006.11.004
Published
2007-00-00
Epub
2006-00-23
Pages
715-26
Language
English
Region
Netherlands
NLM ID
9508482
PMCID
PMC2625401
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 065786 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.biocel.2006.11.004 PMC Full Text View journal details
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