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PMID: 15838603 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The tension mounts: mechanics meets morphogenesis and malignancy.

Journal of mammary gland biology and neoplasia ·Vol. 9 ·No. 4 ·2004-10-00 ·Pages 325-42

Paszek MJ, Weaver VM

Abstract

The tissue microenvironment regulates mammary gland development and tissue homeostasis through soluble, insoluble and cellular cues that operate within the three dimensional architecture of the gland. Disruption of these critical cues and loss of tissue architecture characterize breast tumors. The developing and lactating mammary gland are also subject to a plethora of tensional forces that shape the morphology of the gland and orchestrate its functionally differentiated state. Moreover, malignant transformation of the breast is associated with dramatic changes in gland tension that include elevated compression forces, high tensional resistance stresses and increased extracellular matrix stiffness. Chronically increased mammary gland tension may influence tumor growth, perturb tissue morphogenesis, facilitate tumor invasion, and alter tumor survival and treatment responsiveness. Because mammary tissue differentiation is compromised by high mechanical force and transformed cells exhibit altered mechanoresponsiveness, malignant transformation of the breast may be functionally linked to perturbed tensional-homeostasis. Accordingly, it will be important to define the role of tensional force in mammary gland development and tumorigenesis. Additionally, it will be critical to identify the key molecular elements regulating tensional-homeostasis of the mammary gland and thereafter to characterize their associated mechanotransduction pathways.

MeSH Terms
Animals Biomechanical Phenomena Cell Transformation, Neoplastic Homeostasis Humans Morphogenesis Neoplasms/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Paszek Matthew J
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6383, USA.
Weaver Valerie M
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1007/s10911-004-1404-x
Published
2004-10-00
Pages
325-42
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · CA078731 · United States
NHLBI NIH HHS · HL6438801A1 · United States
External Links
PubMed source DOI: 10.1007/s10911-004-1404-x View journal details
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