Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis.

The Journal of cell biology ·Vol. 67 ·No. 2PT.1 ·1975-11-00 ·Pages 480-4

Sandler JA, Gallin JI, Vaughan M

Abstract

Serotonin, ascorbic acid, and carbamylcholine enhanced the chemotactic responsiveness of human monocytes to endotoxin-treated serum. These agents caused significant accumulation of cyclic GMP in monocytes. PMN leukocyte chemotaxis was also enhanced by these agents although significant increases in cyclic GMP were not demonstrated.

MeSH Terms

Ascorbic Acid/pharmacology Bradykinin/pharmacology Carbachol/pharmacology Chemotaxis/drug effects Cyclic GMP/metabolism Histamine/pharmacology Humans Leukocytes/drug effects,metabolism Monocytes/drug effects,metabolism Neutrophils/drug effects Serotonin/pharmacology

Chemicals

Serotonin Histamine Carbachol Cyclic GMP Ascorbic Acid Bradykinin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Sandler J A

Gallin J I

Vaughan M

References (10)

10 references, click to expand

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.
J Clin Invest. 1975 Feb;55(2):431-5 PMID: 165223
Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery.
J Clin Invest. 1975 May;55(5):1020-5 PMID: 235566
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Scand J Clin Lab Invest Suppl. 1968;97:77-89 PMID: 4179068
Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid.
J Clin Invest. 1974 Mar;53(3):813-8 PMID: 4273024
The effect of Ca2+ and Mg2+ on the chemotactic responsiveness and spontaneous motility of rabbit polymorphonuclear leukocytes.
Z Immunitatsforsch Exp Klin Immunol. 1972 Jun;143(5):466-76 PMID: 4282929
Cyclic GMP and cell movement.
Nature. 1973 Oct 26;245(5426):458-60 PMID: 4356150
Granulocyte chemotaxis: an improved in vitro assay employing 51 Cr-labeled granulocytes.
J Immunol. 1973 Jan;110(1):233-40 PMID: 4685404
The regulatory role of divalent cations in human granulocyte chemotaxis. Evidence for an association between calcium exchanges and microtubule assembly.
J Cell Biol. 1974 Sep;62(3):594-609 PMID: 4855032
Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.
J Clin Invest. 1971 Dec;50(12):2645-52 PMID: 4942966
Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors.
J Immunol. 1972 Mar;108(3):857-60 PMID: 5011759

Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.67.2.480

Published

1975-11-00

Pages

480-4

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2109603

Subset

External Links

PubMed source DOI: 10.1083/jcb.67.2.480 PMC Full Text View journal details

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Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis.

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