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PMID: 17287357 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Adaptations to fluctuating selection in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 104 ·No. 7 ·2007-02-13 ·Pages 2277-82

Mustonen V, Lässig M

Abstract

Time-dependent selection causes the adaptive evolution of new phenotypes, and this dynamics can be traced in genomic data. We have analyzed polymorphisms and substitutions in Drosophila, using a more sensitive inference method for adaptations than the standard population-genetic tests. We find evidence that selection itself is strongly time-dependent, with changes occurring at nearly the rate of neutral evolution. At the same time, higher than previously estimated levels of selection make adaptive responses by a factor 10-100 faster than the pace of selection changes, ensuring that adaptations are an efficient mode of evolution under time-dependent selection. The rate of selection changes is faster in noncoding DNA, i.e., the inference of functional elements can less be based on sequence conservation than for proteins. Our results suggest that selection acts not only as a constraint but as a major driving force of genomic change.

MeSH Terms
Adaptation, Biological/genetics Amino Acid Substitution Animals Drosophila/genetics Evolution, Molecular Genome, Insect Polymorphism, Genetic Selection, Genetic Time Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mustonen Ville
Institut für Theoretische Physik, Universität zu Köln, Zülpicherstrasse 77, 50937 Köln, Germany.
Lässig Michael
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0607105104
Published
2007-02-13
Epub
2007-00-07
Pages
2277-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1892984
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0607105104 PMC Full Text View journal details
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