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PMID: 172912 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Relationship in nucleic acid sequences between mouse mammary tumor virus variants.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 11 ·1975-11-00 ·Pages 4635-9

Michalides R, Schlom J

Abstract

Primary cultures of mouse mammary carcinomas were used as a source of both radioactively labeled and unlabeled 60-70S RNA of mouse mammary tumor virus (MMTV) obtained from various mouse strains. Competition molecular hybridization experiments revealed that, within the limits of the assay, the RNAs of the MMTVs synthesized in culture by the tumors of the mouse strains RIII, GR, A, and C3H, are identical. A comparison of the genomes of the milk-transmitted MMTV(C3H) and the vertically transmitted MMTV(C3Hf) revealed that these two viruses are approximately 75% similar. No nucleic acid sequence homology was observed between MMTV(C3H) 60-70S RNA and the RNAs of murine leukemia virus, Mason-Pfizer virus, or the BrdUrd-induced type-B quinea pig virus.

MeSH Terms
Animals Mammary Tumor Virus, Mouse/analysis Mice Nucleic Acid Hybridization RNA, Viral/analysis Species Specificity
Chemicals
RNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Michalides R
Schlom J
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.11.4635
Published
1975-11-00
Pages
4635-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388778
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.11.4635 PMC Full Text View journal details
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