Abstract
The structural gene encoding DtxR, an iron-dependent diphtheria tox regulatory element, has recently been cloned and sequenced from the C7(-) strain of Corynebacterium diphtheriae (J. M. Boyd, M. Oza, and J. R. Murphy, Proc. Natl. Acad. Sci. USA 87:5972, 1990). We report here the molecular cloning, DNA sequence analysis, and characterization of DtxR from the PW8(-), 1030(-), and C7hm723 strains of C. diphtheriae. While the sequence of dtxR from PW8(-) is identical to that of the C7(-) allele, the sequence of dtxR from the 1030(-) strain is only 91.4% identical; however, the deduced amino acid sequence of DtxR from 1030(-) differs by only 6 of 678 amino acids. Moreover, DtxR from all three strains is shown to regulate expression of beta-galactosidase from a tox promoter-operator (toxPO)-lacZ transcriptional fusion. In contrast, the dtxR allele from the iron-insensitive tox constitutive mutant C7hm723 was found to have a single G----A transition, resulting in a substitution of Arg-47 to His and the loss of tox regulatory activity in recombinant Escherichia coli.
MeSH Terms
Alleles
Amino Acid Sequence
Base Sequence
Blotting, Southern
Cloning, Molecular
Corynebacterium diphtheriae/genetics
Diphtheria Toxin/genetics
Gene Expression Regulation, Bacterial/genetics
Iron/pharmacology
Molecular Sequence Data
Recombinant Fusion Proteins/genetics,metabolism
Regulatory Sequences, Nucleic Acid/genetics
Repressor Proteins/genetics
beta-Galactosidase/genetics,metabolism
Chemicals
Diphtheria Toxin
Recombinant Fusion Proteins
Repressor Proteins
Iron
beta-Galactosidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Boyd J M
Evans Department of Clinical Research, University Hospital, Boston University Medical Center, Massachusetts 02118.
Hall K C
Murphy J R
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