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PMID: 173653 Published · ppublish English Journal Article

Passive immunization in experimental Herpesvirus hominis infection of newborn mice.

Infection and immunity ·Vol. 12 ·No. 6 ·1975-12-00 ·Pages 1258-61

Luyet F, Samra D, Soneji A, Marks MI

Abstract

Infection of newborn mice with Herpesvirus hominis type 2(HVH-2) was used as an experimental model of disseminated HVH infection in newborn humans. Mice were challenged with 103 plaque-forming units of HVH-2 intranasally and were given 0.2 ml of rabbit serum intraperitoneally. Passive immunizations with rabbit anti-HVH-2 serum resulted in a significant decrease in mortality and prolongation of survival time. This effect correlated with the neutralizing antibody titer of the serum against HVH-2 and was more pronounced when immune serum was administered 1 h after infection as compared with 24 h. These results suggest that administration of high-titer anti-HVH-2 immunoglobulins shortly after delivery could afford significant protection to the newborn of a mother with genital HVH-2 infection.

MeSH Terms
Animals Disease Models, Animal Herpes Simplex/immunology Humans Immunity, Maternally-Acquired Immunization, Passive Infant, Newborn Infant, Newborn, Diseases/immunology Mice Neutralization Tests Simplexvirus/pathogenicity
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Luyet F
Samra D
Soneji A
Marks M I
References (35)
35 references, click to expand
  1. Resistance of female mice to vaginal infection induced by Herpesvirus hominis type 2: effects of immunization with Mycobacterium bovis, intravenous injection of specific Herpesvirus hominis type 2 antiserum, and a combination of these procedures.
    Infect Immun. 1974 Dec;10(6):1230-4 PMID: 4373394
  2. Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus.
    Nature. 1974 Sep 27;251(5473):350-2 PMID: 4372535
  3. Herpes simplex infections in hematologic malignancies.
    Am J Med. 1972 Jan;52(1):102-14 PMID: 4550795
  4. Disseminated herpes simplex with encephalitis in a neonate. Treatment with idoxuridine.
    JAMA. 1969 Aug 25;209(8):1219-21 PMID: 5819678
  5. Fulminating infection with herpes-simplex virus in premature and newborn infants.
    N Engl J Med. 1963 Aug 29;269:455-60 PMID: 14000323
  6. PRIMARY DISSEMINATED HERPES SIMPLEX OF THE NEWBORN.
    JAMA. 1965 Feb 8;191:455-60 PMID: 14238025
  7. Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy; report of eight cases and isolation of the virus in one case.
    AMA Am J Dis Child. 1952 Apr;83(4):421-39 PMID: 14902095
  8. Evaluation of four antiviral agents in the treatment of herpes simplex encephalitis in a rat model.
    J Infect Dis. 1975 Jan;131(1):11-6 PMID: 162922
  9. Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells.
    Infect Immun. 1975 Feb;11(2):355-9 PMID: 163220
  10. Diagnosis of Herpesvirus hominis infections in a general hospital laboratory.
    J Clin Microbiol. 1975 Mar;1(3):318-23 PMID: 170310
  11. Effects of anti-lymphoid sera on viral infections.
    Lancet. 1968 Jul 6;2(7558):37-40 PMID: 4172696
  12. The protective effect of different immunoglobulins against herpetic encephalitis and skin infection in guinea pigs.
    Arch Gesamte Virusforsch. 1967;22(3):332-48 PMID: 4176040
  13. Herpes-simplex-virus infection after renal transplantation.
    Lancet. 1969 Oct 25;2(7626):867-71 PMID: 4186453
  14. Disseminated herpes-simplex-virus infections.
    N Engl J Med. 1970 Mar 19;282(12):684-5 PMID: 4190592
  15. Disseminated herpes simplex virus infection. Its pathogenesis based on virological and pathological studies in 33 cases.
    Am J Dis Child. 1968 Jan;115(1):1-8 PMID: 4294710
  16. Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus.
    J Immunol. 1968 Mar;100(3):586-93 PMID: 4296105
  17. Visceral involvement by herpes simplex virus in eczema herpeticum.
    Am J Dis Child. 1968 Sep;116(3):324-7 PMID: 4300208
  18. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.
    J Immunol. 1970 May;104(5):1155-9 PMID: 4315460
  19. Infection of the newborn with herpesvirus hominis.
    Adv Pediatr. 1970;17:185-226 PMID: 4319813
  20. Method for the preparation of a herpesvirus hominis fluorescent conjugate for direct immunofluorescence.
    Arch Gesamte Virusforsch. 1970;32(4):373-8 PMID: 4322850
  21. Perinatal risk associated with maternal genital herpes simplex virus infection.
    Am J Obstet Gynecol. 1971 Jul 15;110(6):825-37 PMID: 4327295
  22. Visceral herpesvirus infections in patients with cancer.
    Am J Clin Pathol. 1971 Oct;56(4):459-65 PMID: 4329705
  23. Prevention of cell-to-cell spread of herpes simplex virus by leukocytes.
    J Exp Med. 1973 Mar 1;137(3):706-20 PMID: 4347596
  24. The action of human immunoglobulins in experimental herpes infection in the newborn rat.
    Rev Roum Virol. 1973;10(1):47-58 PMID: 4350924
  25. Host defense mechanisms against Herpes simplex virus. I. Control of infection in vitro by senstized spleen cells and antibody.
    Infect Immun. 1973 Jun;7(6):898-904 PMID: 4351970
  26. Infection with herpes-simplex viruses 1 and 2. 1.
    N Engl J Med. 1973 Sep 27;289(13):667-74 PMID: 4353825
  27. Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine.
    J Infect Dis. 1973 Sep;128(3):290-9 PMID: 4353930
  28. Zoster immune globulin. A further assessment.
    N Engl J Med. 1974 Jan 31;290(5):243-5 PMID: 4358055
  29. Cell-mediated immunity to herpes simplex virus in man.
    J Infect Dis. 1974 Feb;129(2):142-6 PMID: 4359402
  30. Induction of cellular immunity to herpes simplex virus: relationship to the humoral immune response.
    J Immunol. 1974 Mar;112(3):1019-25 PMID: 4359780
  31. Lymphocyte interferon production and transformation after Herpes simplex infections in humans.
    J Immunol. 1974 Feb;112(2):728-36 PMID: 4360547
  32. Herpesvirus hominis infections in the fetus and the newborn.
    Am J Dis Child. 1973 Oct;126(4):546-55 PMID: 4361339
  33. Cellular immunity to herpes simplex virus mediated by interferon.
    J Exp Med. 1974 Sep 1;140(3):764-78 PMID: 4369835
  34. Stimulation of peripheral blood lymphocytes by herpes simplex virus in vitro.
    Infect Immun. 1974 Sep;10(3):430-6 PMID: 4372170
  35. Neonatal herpes simplex infection following delivery by cesarean section.
    Obstet Gynecol. 1974 Oct;44(4):496-9 PMID: 4414784
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.12.6.1258-1261.1975
Published
1975-12-00
Pages
1258-61
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415429
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.12.6.1258-1261.1975 PMC Full Text View journal details
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