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PMID: 17386255 Published · ppublish English Comment Journal Article

miRNA editing--we should have inosine this coming.

Molecular cell ·Vol. 25 ·No. 6 ·2007-03-23 ·Pages 792-3

Habig JW, Dale T, Bass BL

Abstract

In a recent issue of Science, Nishikura and colleagues provide the first evidence that editing of a microRNA (miRNA) precursor by ADARs can modulate the target specificity of the mature miRNA (Kawahara et al., 2007).

MeSH Terms
Animals Humans Inosine/metabolism Introns MicroRNAs/genetics RNA Editing/genetics RNA Interference RNA, Double-Stranded/metabolism RNA, Small Interfering/genetics
Chemicals
MicroRNAs RNA, Double-Stranded RNA, Small Interfering Inosine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Habig Jeffrey W
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA; Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA.
Dale Taraka
Bass Brenda L
References (9)
9 references, click to expand
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    Mol Cell. 2002 Oct;10(4):809-17 PMID: 12419225
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    Cell. 2004 Jan 23;116(2):281-97 PMID: 14744438
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  4. Identification of microRNAs of the herpesvirus family.
    Nat Methods. 2005 Apr;2(4):269-76 PMID: 15782219
  5. The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.
    Nat Struct Mol Biol. 2005 Jun;12(6):489-96 PMID: 15895094
  6. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases.
    Nat Struct Mol Biol. 2006 Jan;13(1):13-21 PMID: 16369484
  7. RNA editing of human microRNAs.
    Genome Biol. 2006;7(4):R27 PMID: 16594986
  8. Editor meets silencer: crosstalk between RNA editing and RNA interference.
    Nat Rev Mol Cell Biol. 2006 Dec;7(12):919-31 PMID: 17139332
  9. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs.
    Science. 2007 Feb 23;315(5815):1137-40 PMID: 17322061
Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-2765
DOI
10.1016/j.molcel.2007.03.010
Published
2007-03-23
Pages
792-3
Language
English
Region
United States
NLM ID
9802571
PMCID
PMC2583401
Subset
IM
Grants
NIGMS NIH HHS · R01 GM067106 · United States
NIGMS NIH HHS · R01 GM067106-04 · United States
Corrections
CommentOn
PMID: 17139332
External Links
PubMed source DOI: 10.1016/j.molcel.2007.03.010 PMC Full Text View journal details
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