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PMID: 17139332 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Editor meets silencer: crosstalk between RNA editing and RNA interference.

Nature reviews. Molecular cell biology ·Vol. 7 ·No. 12 ·2006-12-00 ·Pages 919-31

Nishikura K

Abstract

The most prevalent type of RNA editing is mediated by ADAR (adenosine deaminase acting on RNA) enzymes, which convert adenosines to inosines (a process known as A-->I RNA editing) in double-stranded (ds)RNA substrates. A-->I RNA editing was long thought to affect only selected transcripts by altering the proteins they encode. However, genome-wide screening has revealed numerous editing sites within inverted Alu repeats in introns and untranslated regions. Also, recent evidence indicates that A-->I RNA editing crosstalks with RNA-interference pathways, which, like A-->I RNA editing, involve dsRNAs. A-->I RNA editing therefore seems to have additional functions, including the regulation of retrotransposons and gene silencing, which adds a new urgency to the challenges of fully understanding ADAR functions.

MeSH Terms
Adenosine/chemistry,metabolism Adenosine Deaminase/chemistry,genetics,metabolism Alu Elements Animals Gene Expression Regulation Humans Inosine/chemistry,metabolism Introns RNA Editing RNA Interference RNA, Double-Stranded/metabolism RNA, Small Interfering/metabolism RNA-Binding Proteins Retroelements
Chemicals
RNA, Double-Stranded RNA, Small Interfering RNA-Binding Proteins Retroelements Inosine ADARB1 protein, human Adenosine Deaminase Adenosine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nishikura Kazuko
The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104-4268, USA. [email protected]
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/nrm2061
Email
[email protected]
Published
2006-12-00
Pages
919-31
Language
English
Region
England
NLM ID
100962782
PMCID
PMC2953463
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040536 · United States
NHLBI NIH HHS · R01 HL070045 · United States
NIGMS NIH HHS · R01 GM040536-15 · United States
NCI NIH HHS · P01 CA072765 · United States
NCI NIH HHS · P01 CA072765-050002 · United States
NHLBI NIH HHS · R01 HL070045-04 · United States
Corrections
CommentIn
PMID: 17386255
External Links
PubMed source DOI: 10.1038/nrm2061 PMC Full Text View journal details
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