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PMID: 17471263 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells.

EMBO reports ·Vol. 8 ·No. 5 ·2007-05-00 ·Pages 465-9

Wolf A, Schmitz C, Böttger A

Abstract

The phosphatidylserine receptor (PSR) was originally described as the putative receptor for phosphatidylserine, which is displayed on the outer membrane leaflet of apoptotic cells as a so-called 'eat me' signal. Since then, contradictory findings about this protein have been published. A common characteristic of all PSR loss-of-function experiments in vertebrates has been neonatal lethality accompanied by severe developmental defects. However, impairment of phagocytosis has only been detected in some of these experiments. Furthermore, several groups have shown that PSR localizes to the nucleus. Structural in silico analysis of PSR indicates that it has a JumonjiC domain, and the molecular features characteristic of Fe(II)-dependent and 2-oxoglutarate-dependent oxygenases. This review summarizes the current status of research on the PSR protein.

MeSH Terms
Amino Acid Sequence Animals Apoptosis Humans Models, Molecular Molecular Sequence Data Phagocytosis Protein Structure, Tertiary Receptors, Cell Surface/chemistry,metabolism Sequence Alignment Signal Transduction
Chemicals
Receptors, Cell Surface phosphatidylserine receptor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wolf Alexander
Department of Biology II, Ludwig-Maximilians-University, Grosshaderner Strasse 2, D-82152 Planegg-Martinsried, Germany.
Schmitz Corinna
Böttger Angelika
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7400956
Published
2007-05-00
Pages
465-9
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1866200
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7400956 PMC Full Text View journal details
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