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PMID: 17585884 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder.

Biological psychiatry ·Vol. 62 ·No. 9 ·2007-11-01 ·Pages 991-8

Bidwell LC, Willcutt EG, Defries JC, Pennington BF

Abstract

Neurocognitive deficits associated with attention-deficit/hyperactivity disorder (ADHD) might be useful intermediate endophenotypes for determining specific genetic pathways that contribute to ADHD. This study administered 17 measures from prominent neuropsychological theories of ADHD (executive function, processing speed, arousal regulation and, motivation/delay aversion) in dizygotic (DZ) twin pairs discordant for ADHD and control twin pairs (ages 8-18 years) to compare performance between twins affected with ADHD (n = 266), their unaffected co-twins (n = 228), and control children from twin pairs without ADHD or learning difficulties (n = 332). The ADHD subjects show significant impairment on executive function, processing speed, and response variability measures compared with control subjects. Unaffected co-twins of ADHD subjects are significantly impaired on nearly all the same measures as their ADHD siblings, even when subclinical symptoms of ADHD are controlled. Executive function, processing speed, and response variability deficits might be useful endophenotypes for genetic studies of ADHD.

MeSH Terms
Adolescent Analysis of Variance Attention Deficit Disorder with Hyperactivity/genetics,physiopathology Child Cognition Disorders/genetics,physiopathology Diseases in Twins/genetics,psychology Female Genetic Predisposition to Disease/genetics Humans Intelligence Tests Male Neuropsychological Tests/statistics & numerical data Phenotype Problem Solving Reading Sex Factors Twins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bidwell L Cinnamon
Department of Psychology, University of Colorado, Boulder, Colorado, USA. [email protected]
Willcutt Erik G
Defries John C
Pennington Bruce F
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Article Info
Journal
Biological psychiatry
Abbr.
Biol Psychiatry
ISSN
0006-3223
DOI
10.1016/j.biopsych.2007.04.003
Email
[email protected]
Published
2007-11-01
Epub
2007-00-22
Pages
991-8
Language
English
Region
United States
NLM ID
0213264
PMCID
PMC2687149
Subset
IM
Grants
NIMH NIH HHS · R01 MH063941-01 · United States
NIMH NIH HHS · R01 MH063941-05 · United States
NIMH NIH HHS · R01 MH62120 · United States
NIMH NIH HHS · R37 MH038820 · United States
NICHD NIH HHS · P50 HD027802 · United States
NIMH NIH HHS · R01 MH062120-01 · United States
NICHD NIH HHS · P30 HD004024-339004 · United States
NIMH NIH HHS · F31 MH078514-02 · United States
NIMH NIH HHS · R01 MH063941-02 · United States
NICHD NIH HHS · P30 HD004024-349004 · United States
NICHD NIH HHS · P50 HD-27802 · United States
NIMH NIH HHS · R01 MH063941-04 · United States
NIMH NIH HHS · R01 MH062120-04 · United States
NIMH NIH HHS · R01 MH062120-02 · United States
NICHD NIH HHS · P30 HD004024-329004 · United States
NIMH NIH HHS · R01 MH062120 · United States
NIMH NIH HHS · R01 MH038820 · United States
NIMH NIH HHS · R01 MH063941-03 · United States
NIMH NIH HHS · F31 MH078514 · United States
NIMH NIH HHS · R01 MH63941 · United States
NIMH NIH HHS · R01 MH062120-03 · United States
NIMH NIH HHS · MH 38820 · United States
NICHD NIH HHS · P30 HD004024-309004 · United States
NICHD NIH HHS · P30 HD004024-319004 · United States
NIMH NIH HHS · MH04024 · United States
NIMH NIH HHS · R01 MH063941 · United States
NIMH NIH HHS · R01 MH062120-05 · United States
NIMH NIH HHS · F31 MH078514-01 · United States
External Links
PubMed source DOI: 10.1016/j.biopsych.2007.04.003 PMC Full Text View journal details
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