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PMID: 17628466 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Lysosome-related organelles: driving post-Golgi compartments into specialisation.

Current opinion in cell biology ·Vol. 19 ·No. 4 ·2007-08-00 ·Pages 394-401

Raposo G, Marks MS, Cutler DF

Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

MeSH Terms
Animals Cell Compartmentation/physiology Endosomes/metabolism Golgi Apparatus/physiology Humans Lysosomes/physiology Melanosomes/physiology Organelles/physiology Protein Sorting Signals rab GTP-Binding Proteins/physiology rab27 GTP-Binding Proteins
Chemicals
Protein Sorting Signals rab27 GTP-Binding Proteins RAB27A protein, human rab GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Raposo Graça
Institut Curie, Centre de Recherche, Paris F-75248, France. [email protected]
Marks Michael S
Cutler Daniel F
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2007.05.001
Email
[email protected]
Published
2007-08-00
Epub
2007-00-12
Pages
394-401
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2782641
Subset
IM
Grants
NIAMS NIH HHS · R01 AR048155-06 · United States
NEI NIH HHS · R01 EY015625 · United States
NEI NIH HHS · R01 EY015625-05 · United States
NIAMS NIH HHS · R01 AR048155 · United States
Medical Research Council · MC_U122665003 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.ceb.2007.05.001 PMC Full Text View journal details
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