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PMID: 17662717 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury.

Experimental neurology ·Vol. 209 ·No. 2 ·2008-02-00 ·Pages 378-88

Donnelly DJ, Popovich PG

Abstract

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.

MeSH Terms
Animals Axons/physiology Humans Inflammation/physiopathology Recovery of Function/physiology Regeneration/physiology Spinal Cord Injuries/metabolism,pathology,physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Donnelly Dustin J
The Integrated Biomedical Science Graduate Program, Department of Molecular Virology, Immunology & Medical Genetics, The Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Popovich Phillip G
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Article Info
Journal
Experimental neurology
Abbr.
Exp Neurol
ISSN
0014-4886
DOI
10.1016/j.expneurol.2007.06.009
Published
2008-02-00
Epub
2007-00-30
Pages
378-88
Language
English
Region
United States
NLM ID
0370712
PMCID
PMC2692462
Subset
IM
Grants
NINDS NIH HHS · R01 NS037846 · United States
NINDS NIH HHS · R01 NS037846-05 · United States
NINDS NIH HHS · NS 746703 · United States
External Links
PubMed source DOI: 10.1016/j.expneurol.2007.06.009 PMC Full Text View journal details
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