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PMID: 17690945 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Serotonin transporter gene polymorphism and the phenotypic heterogeneity of adult ADHD.

Journal of neural transmission (Vienna, Austria : 1996) ·Vol. 114 ·No. 12 ·2007-00-00 ·Pages 1631-6

Grevet EH, Marques FZ, Salgado CA, Fischer AG, Kalil KL, Victor MM, Garcia CR, Sousa NO, Belmonte-de-Abreu P, Bau CH

Abstract

The present study investigates possible associations between the 5-HTT control region polymorphism (5-HTTLPR) with adult ADHD, including subtypes, severity, temperament profile and comorbidities. The polymorphic site was genotyped in 312 adult patients with ADHD and 236 controls, all of them Brazilians of European descent. The interviews followed the DSM-IV criteria, using the K-SADS-E for ADHD and oppositional defiant disorder, SCID-I and MINI for comorbidities and the TCI for temperament dimensions. The 5-HTTLPR polymorphism was not associated with ADHD. Carriers of the S allele presented slightly higher inattention and novelty seeking scores, and a higher frequency of drug dependence. These differences do not persist after correction for multiple comparisons. These results suggest that the 5-HTTLPR polymorphism does not have a direct role in the predisposition to adult ADHD. There is suggestive evidence for a small effect in some behavioral phenotypes related to ADHD.

MeSH Terms
Adult Attention Deficit Disorder with Hyperactivity/genetics Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Male Phenotype Polymerase Chain Reaction Polymorphism, Genetic Serotonin Plasma Membrane Transport Proteins/genetics
Chemicals
Serotonin Plasma Membrane Transport Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Grevet E H
Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Marques F Z C
Salgado C A I
Fischer A G
Kalil K L
Victor M M
Garcia C R
Sousa N O
Belmonte-de-Abreu P
Bau C H D
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Article Info
Journal
Journal of neural transmission (Vienna, Austria : 1996)
Abbr.
J Neural Transm (Vienna)
ISSN
0300-9564
DOI
10.1007/s00702-007-0797-2
Published
2007-00-00
Epub
2007-00-10
Pages
1631-6
Language
English
Region
Austria
NLM ID
9702341
Subset
IM
External Links
PubMed source DOI: 10.1007/s00702-007-0797-2 View journal details
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