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PMID: 177401 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Growth rate modulation of four aminoacyl-transfer ribonucleic acid synthetases in enteric bacteria.

Journal of bacteriology ·Vol. 126 ·No. 2 ·1976-05-00 ·Pages 634-45

McKeever WG, Neidhardt FC

Abstract

The specific activities of arginyl- glutamyl- seryl-, and valyl-transfer ribonucleic acid (tRNA) synthetases were measured in the wild-type and mutant strains of Salmonella typhimurium LT2 and Escherichia coli B/r. In media restricted only by carbon and energy source availability, the specific activities of all four enzymes were proportional to the growth rate, with the exception of seryl-tRNA synthetase in S. typhimurium, which remained essentially constant. Structural gene densities were calculated for these four enzymes and were found not to account for the variation of specific activity with growth rate.

MeSH Terms
Amino Acids/metabolism Amino Acyl-tRNA Synthetases/metabolism Arginine-tRNA Ligase/metabolism Bacterial Proteins/biosynthesis Cell-Free System Cyclic AMP/metabolism Enzyme Repression Escherichia coli/enzymology,growth & development,metabolism Genes Glutamate-tRNA Ligase/metabolism Mutation Ornithine Carbamoyltransferase/metabolism RNA, Bacterial/biosynthesis Salmonella typhimurium/enzymology,growth & development,metabolism Serine-tRNA Ligase/metabolism Threonine Dehydratase/metabolism Valine-tRNA Ligase/metabolism
Chemicals
Amino Acids Bacterial Proteins RNA, Bacterial Cyclic AMP Ornithine Carbamoyltransferase Threonine Dehydratase Amino Acyl-tRNA Synthetases Serine-tRNA Ligase Glutamate-tRNA Ligase Arginine-tRNA Ligase Valine-tRNA Ligase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McKeever W G
Neidhardt F C
References (19)
19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.126.2.634-645.1976
Published
1976-05-00
Pages
634-45
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC233196
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.126.2.634-645.1976 PMC Full Text View journal details
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