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PMID: 1783293 Published · ppublish English Comparative Study Journal Article

Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution.

Genetics ·Vol. 129 ·No. 4 ·1991-12-00 ·Pages 1085-98

Montgomery EA, Huang SM, Langley CH, Judd BH

Abstract

Ectopic recombination between interspersed repeat sequences generates chromosomal rearrangements that have a major impact on genome structure. A survey of ectopic recombination in the region flanking the white locus of Drosophila melanogaster identified 25 transposon-mediated rearrangements from four parallel experiments. Eighteen of the 25 were generated from females carrying X chromosomes heterozygous for interspersed repeat sequences. The cytogenetic and molecular analyses of the rearrangements and the parental chromosomes show: (1) interchromosomal and intrachromosomal recombinants are generated in about equal numbers; (2) ectopic recombination appears to be a meiotic process that is stimulated by the interchromosomal effect to about the same degree as regular crossing over; (3) copies of the retrotransposon roo were involved in all of the interchromosomal exchanges; some copies were involved much more frequently than others in the target region; (4) homozygosis for interspersed repeat sequences and other sequence variations significantly reduced ectopic recombination.

MeSH Terms
Animals Biological Evolution Crosses, Genetic Drosophila melanogaster/genetics Eye Color/genetics Female Genes Genetics, Population Heterozygote Homozygote Male Recombination, Genetic Repetitive Sequences, Nucleic Acid Restriction Mapping Saccharomyces cerevisiae/genetics Translocation, Genetic X Chromosome
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Montgomery E A
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Huang S M
Langley C H
Judd B H
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/129.4.1085
Published
1991-12-00
Pages
1085-98
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1204773
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/129.4.1085 PMC Full Text View journal details
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