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PMID: 17904621 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Sex differences in drug abuse.

Frontiers in neuroendocrinology ·Vol. 29 ·No. 1 ·2008-01-00 ·Pages 36-47

Becker JB, Hu M

Abstract

Sex differences are present for all of the phases of drug abuse (initiation, escalation of use, addiction, and relapse following abstinence). While there are some differences among specific classes of abused drugs, the general pattern of sex differences is the same for all drugs of abuse. Females begin regularly self-administering licit and illicit drugs of abuse at lower doses than do males, use escalates more rapidly to addiction, and females are at greater risk for relapse following abstinence. In this review, sex differences in drug abuse are discussed for humans and in animal models. The possible neuroendocrine mechanisms mediating these sex differences are discussed.

MeSH Terms
Animals Cocaine/administration & dosage,pharmacology Corpus Striatum/drug effects Disease Models, Animal Dose-Response Relationship, Drug Estradiol/physiology Estrogen Receptor alpha/physiology Estrous Cycle/drug effects,physiology Ethanol/administration & dosage,pharmacology Female Humans Male Models, Biological Narcotics/administration & dosage,pharmacology Nicotine/administration & dosage,pharmacology Psychomotor Performance/drug effects Risk Factors Sex Characteristics Sex Chromosomes/physiology Substance-Related Disorders/etiology,genetics
Chemicals
Estrogen Receptor alpha Narcotics Ethanol Estradiol Nicotine Cocaine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Becker Jill B
Psychology Department, University of Michigan, Ann Arbor, MI 48109, USA. [email protected]
Hu Ming
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Article Info
Journal
Frontiers in neuroendocrinology
Abbr.
Front Neuroendocrinol
ISSN
1095-6808
DOI
10.1016/j.yfrne.2007.07.003
Email
[email protected]
Published
2008-01-00
Epub
2007-00-24
Pages
36-47
Language
English
Region
United States
NLM ID
7513292
PMCID
PMC2235192
Subset
IM
Grants
NIDA NIH HHS · DA12677 · United States
NIDA NIH HHS · R01 DA012677-08 · United States
NINDS NIH HHS · R01 NS048141-04 · United States
NIDA NIH HHS · R01 DA012677-06 · United States
NINDS NIH HHS · R01 NS048141 · United States
NIDA NIH HHS · R01 DA012677 · United States
NINDS NIH HHS · R01 NS048141-03 · United States
NIDA NIH HHS · R01 DA012677-07 · United States
External Links
PubMed source DOI: 10.1016/j.yfrne.2007.07.003 PMC Full Text View journal details
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