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PMID: 179096 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of concanavalin A and a succinylated derivative on lymphocyte proliferation and cyclic nucleotide levels.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 5 ·1976-05-00 ·Pages 1717-21

Hadden JW, Hadden EM, Sadlik JR, Coffey RG

Abstract

To better define cell surface-related changes involved in lymphocyte activation, we studied native concanavalin A (Con A) and succinylated concanavalin A (Suc-Con A) for their effects on proliferation and cyclic nucleotide levels of human peripheral blood lymphocytes. At optimal mitogenic concentrations, the two forms of Con A induce equivalent proliferation; however, the mitogenic activity of Con A progressively decreases above 50 mug/ml. In contrast, the mitogenic activity of Suc-Con A is not decreased even at 250 mug/ml.

MeSH Terms
Cell Division Cell Membrane/ultrastructure Concanavalin A/analogs & derivatives,pharmacology Cyclic AMP/metabolism Cyclic GMP/metabolism Dose-Response Relationship, Drug Humans Kinetics Lymphocyte Activation/drug effects Lymphocytes/metabolism,physiology,ultrastructure Structure-Activity Relationship
Chemicals
Concanavalin A Cyclic AMP Cyclic GMP
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hadden J W
Hadden E M
Sadlik J R
Coffey R G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.5.1717
Published
1976-05-00
Pages
1717-21
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430371
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.5.1717 PMC Full Text View journal details
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