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PMID: 17915085 Published · ppublish English Journal Article Review

ADHD genetics: 2007 update.

Current psychiatry reports ·Vol. 9 ·No. 5 ·2007-10-00 ·Pages 434-9

Elia J, Devoto M

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is highly heritable. Confirmed association has been reported for several candidate genes, including DAT1, DRD4, SNAP-25, DRD5, 5HTT, HTR1B, and DBH; however, these confer relatively small risk. Family-based linkage studies have identified a number of chromosomal regions containing potential ADHD predisposing loci, some overlapping in two or more studies, including 5p, 6q, 7p, 11q, 12q, and 17p. New large-scale studies that apply recent technological advances to perform high-density genotyping of the entire genome, in combination with information on the haplotype structure of the human genome, now allow testing of single-nucleotide polymorphism association with disease phenotype without any a priori hypothesis. They may contribute further to our understanding of the genetic factors involved in ADHD. The heterogeneous complex ADHD phenotype, as well as epigenetic factors may be contributing to the challenge of genetic studies. Samples that include limited age ranges may have better success at uncovering genes whose expression is limited to specific developmental stages.

MeSH Terms
Attention Deficit Disorder with Hyperactivity/diagnosis,genetics Chromosome Mapping Epigenesis, Genetic/genetics Genetic Markers/genetics Genetic Predisposition to Disease/genetics Genotype Haplotypes Humans Phenotype Polymorphism, Single Nucleotide/genetics Social Environment
Chemicals
Genetic Markers
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Elia Josephine
The Children's Hospital of Philadelphia, Science Center, 3440 Market Street, Philadelphia, PA 19104-6209, USA. [email protected]
Devoto Marcella
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Article Info
Journal
Current psychiatry reports
Abbr.
Curr Psychiatry Rep
ISSN
1523-3812
DOI
10.1007/s11920-007-0057-z
Email
[email protected]
Published
2007-10-00
Pages
434-9
Language
English
Region
United States
NLM ID
100888960
Subset
IM
External Links
PubMed source DOI: 10.1007/s11920-007-0057-z View journal details
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