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PMID: 1794049 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 1 ·No. 4 ·1991-00-00 ·Pages 206-10

Aitman TJ, Hearne CM, McAleer MA, Todd JA

Abstract

Microsatellite sequences, such as dinucleotide repeats, show a high degree of polymorphism in eukaryotic DNA. These sequences are convenient as genetic markers and can be analyzed by the polymerase chain reaction (PCR). We have assessed the frequency of length variants in 18 mononucleotide repeats in mouse DNA and find that the variability is similar to that reported for dinucleotide repeats. Nine of the 18 repeat sequences (50%) have three or more alleles in the strains tested. Ten of these repeat sequences have been mapped using strain distribution patterns (SDPs) in recombinant inbred (RI) strains.

MeSH Terms
Animals Base Sequence Chromosome Mapping DNA, Satellite Mice Molecular Sequence Data Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid
Chemicals
DNA, Satellite
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Aitman T J
Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, UK.
Hearne C M
McAleer M A
Todd J A
References (18)
18 references, click to expand
  1. An interspecific backcross linkage map of the proximal half of mouse chromosome 14.
    Genomics. 1990 Apr;6(4):673-8 PMID: 1971251
  2. A high frequency of length polymorphisms in repeated sequences adjacent to Alu sequences.
    Am J Hum Genet. 1990 May;46(5):963-9 PMID: 2339694
  3. A new family of interspersed repetitive DNA sequences in the mouse genome.
    J Mol Biol. 1982 May 25;157(3):453-71 PMID: 6927852
  4. The gene and the pseudogene for mouse p53 cellular tumor antigen are located on different chromosomes.
    Mol Cell Biol. 1984 Aug;4(8):1638-40 PMID: 6387444
  5. Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites.
    Nucleic Acids Res. 1990 Jul 25;18(14):4123-30 PMID: 2377456
  6. Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
    Genetics. 1990 Sep;126(1):277-84 PMID: 2227386
  7. Isolation and characterization of the oligo(dA-dT) clusters and their flanking DNA segments in the rabbit genome.
    J Mol Biol. 1977 Oct 5;115(4):715-35 PMID: 592377
  8. Hypervariability of simple sequences as a general source for polymorphic DNA markers.
    Nucleic Acids Res. 1989 Aug 25;17(16):6463-71 PMID: 2780284
  9. A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6465-9 PMID: 6755470
  10. Simple sequences are ubiquitous repetitive components of eukaryotic genomes.
    Nucleic Acids Res. 1984 May 25;12(10):4127-38 PMID: 6328411
  11. The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.
    Proc Natl Acad Sci U S A. 1990 Apr;87(8):2951-4 PMID: 2326257
  12. A comprehensive set of sequence analysis programs for the VAX.
    Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 PMID: 6546423
  13. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
    Am J Hum Genet. 1989 Mar;44(3):388-96 PMID: 2916582
  14. Deoxyadenylate-rich and deoxyguanylate-rich regions in mammalian DNA.
    J Mol Biol. 1974 May 5;85(1):19-39 PMID: 4835727
  15. A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.
    Am J Hum Genet. 1989 Mar;44(3):397-401 PMID: 2563634
  16. DNA sequence polymorphisms in Alu repeats.
    Genomics. 1990 Oct;8(2):271-8 PMID: 1979049
  17. Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms.
    Genomics. 1990 Aug;7(4):524-30 PMID: 1974878
  18. Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice.
    J Virol. 1989 Sep;63(9):3810-21 PMID: 2547997
Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/BF00352326
Published
1991-00-00
Pages
206-10
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00352326 View journal details
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