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PMID: 2326257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 8 ·1990-04-00 ·Pages 2951-4

Economou EP, Bergen AW, Warren AC, Antonarakis SE

Abstract

To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the beta-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.

MeSH Terms
Alleles Base Sequence Female Gene Amplification Genome, Human Humans Male Molecular Sequence Data Oligonucleotide Probes Pedigree Poly A/genetics Polymorphism, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
Oligonucleotide Probes Poly A poly(dA)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Economou E P
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Bergen A W
Warren A C
Antonarakis S E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.8.2951
Published
1990-04-00
Pages
2951-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53811
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.87.8.2951 PMC Full Text View journal details
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