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PMID: 17942367 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Neuroglobin: an endogenous neuroprotectant.

Current opinion in pharmacology ·Vol. 8 ·No. 1 ·2008-02-00 ·Pages 20-4

Greenberg DA, Jin K, Khan AA

Abstract

Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic-ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces--and knocking down Ngb expression increases--hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.

MeSH Terms
Animals Globins/genetics,physiology Humans Hypoxia-Ischemia, Brain/prevention & control Nerve Tissue Proteins/genetics,physiology Neurodegenerative Diseases/prevention & control Neuroglobin Neuroprotective Agents Nitric Oxide/metabolism
Chemicals
Nerve Tissue Proteins Neuroglobin Neuroprotective Agents Nitric Oxide Globins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Greenberg David A
Buck Institute for Age Research, Novato, CA 94549, USA. [email protected]
Jin Kunlin
Khan Adil A
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Article Info
Journal
Current opinion in pharmacology
Abbr.
Curr Opin Pharmacol
ISSN
1471-4892
DOI
10.1016/j.coph.2007.09.003
Email
[email protected]
Published
2008-02-00
Epub
2007-00-17
Pages
20-4
Language
English
Region
England
NLM ID
100966133
PMCID
PMC2387246
Subset
IM
Grants
NINDS NIH HHS · P01 NS035965 · United States
NINDS NIH HHS · P01 NS035965-100002 · United States
NINDS NIH HHS · NS35965 · United States
External Links
PubMed source DOI: 10.1016/j.coph.2007.09.003 PMC Full Text View journal details
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