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PMID: 17943193 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Recent and ongoing selection in the human genome.

Nature reviews. Genetics ·Vol. 8 ·No. 11 ·2007-11-00 ·Pages 857-68

Nielsen R, Hellmann I, Hubisz M, Bustamante C, Clark AG

Abstract

The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

MeSH Terms
Evolution, Molecular Genetics, Population Genome, Human Humans Selection, Genetic
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nielsen Rasmus
Center for Comparative Genomics, University of Copenhagen, Universitetsparken 15, 2100 Kbh Ø, Denmark. [email protected]
Hellmann Ines
Hubisz Melissa
Bustamante Carlos
Clark Andrew G
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2187
Email
[email protected]
Published
2007-11-00
Pages
857-68
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2933187
Subset
IM
Grants
NHGRI NIH HHS · R01HG003229 · United States
NHGRI NIH HHS · R01 HG003229 · United States
NHLBI NIH HHS · U01 HL084706 · United States
NHGRI NIH HHS · R01 HG003229-03 · United States
NHLBI NIH HHS · U01HL084706 · United States
External Links
PubMed source DOI: 10.1038/nrg2187 PMC Full Text View journal details
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