Reversal of fortune: Rad5 to the rescue.

Molecular cell ·Vol. 28 ·No. 2 ·2007-10-26 ·Pages 181-3

Klein HL

Abstract

In a recent issue of Molecular Cell, Blastyák et al. (2007) show that the yeast Rad5 protein can promote error-free template switching and replication past a DNA lesion via a novel DNA unwinding reaction that also pairs nascent and parental strands.

MeSH Terms

Adenosine Triphosphatases/metabolism DNA Breaks, Double-Stranded DNA Helicases DNA Repair DNA Replication DNA, Fungal/metabolism DNA-Directed DNA Polymerase/metabolism Exodeoxyribonucleases/metabolism Saccharomyces cerevisiae/enzymology,genetics,metabolism Saccharomyces cerevisiae Proteins/metabolism Ubiquitin-Conjugating Enzymes/metabolism Ubiquitin-Protein Ligases/metabolism

Chemicals

DNA, Fungal MMS2 protein, S cerevisiae Saccharomyces cerevisiae Proteins UBC13 protein, S cerevisiae Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases DNA-Directed DNA Polymerase Exodeoxyribonucleases exodeoxyribonuclease I Adenosine Triphosphatases RAD5 protein, S cerevisiae DNA Helicases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Klein Hannah L

Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA. [email protected]

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/j.molcel.2007.10.001

[email protected]

Published

2007-10-26

Pages

181-3

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 17936713

External Links

PubMed source DOI: 10.1016/j.molcel.2007.10.001 View journal details

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