Home LiteratureArticle Details
PMID: 17989245 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A second-generation combined linkage physical map of the human genome.

Genome research ·Vol. 17 ·No. 12 ·2007-12-00 ·Pages 1783-6

Matise TC, Chen F, Chen W, De La Vega FM, Hansen M, He C, Hyland FC, Kennedy GC, Kong X, Murray SS, Ziegle JS, Stewart WC, Buyske S

Abstract

We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.

MeSH Terms
Confidence Intervals Female Genetic Linkage Genetic Markers Genome, Human Genotype Humans Male Physical Chromosome Mapping/methods,statistics & numerical data Polymorphism, Single Nucleotide
Chemicals
Genetic Markers
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Matise Tara C
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA. [email protected]
Chen Fang
Chen Wenwei
De La Vega Francisco M
Hansen Mark
He Chunsheng
Hyland Fiona C L
Kennedy Giulia C
Kong Xiangyang
Murray Sarah S
Ziegle Janet S
Stewart William C L
Buyske Steven
References (17)
17 references, click to expand
  1. A map of the human genome in linkage disequilibrium units.
    Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11835-9 PMID: 16091463
  2. A high-resolution recombination map of the human genome.
    Nat Genet. 2002 Jul;31(3):241-7 PMID: 12053178
  3. The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis.
    Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2228-33 PMID: 11842208
  4. Construction of multilocus genetic linkage maps in humans.
    Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363-7 PMID: 3470801
  5. Bias in multipoint linkage analysis arising from map misspecification.
    Genet Epidemiol. 2000 Dec;19(4):366-80 PMID: 11108646
  6. Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE.
    Bioinformatics. 2007 Jan 1;23(1):64-70 PMID: 17060360
  7. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome.
    Genomics. 1990 Mar;6(3):575-7 PMID: 2184120
  8. Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.
    Nat Genet. 2002 Jan;30(1):97-101 PMID: 11731797
  9. A combined linkage-physical map of the human genome.
    Am J Hum Genet. 2004 Dec;75(6):1143-8 PMID: 15486828
  10. Multipoint linkage analysis. A cautionary note.
    Hum Hered. 1999 Jul;49(4):194-6 PMID: 10436380
  11. PedCheck: a program for identification of genotype incompatibilities in linkage analysis.
    Am J Hum Genet. 1998 Jul;63(1):259-66 PMID: 9634505
  12. Large-scale genotyping of complex DNA.
    Nat Biotechnol. 2003 Oct;21(10):1233-7 PMID: 12960966
  13. A highly informative SNP linkage panel for human genetic studies.
    Nat Methods. 2004 Nov;1(2):113-7 PMID: 15782173
  14. A multimarker regression-based test of linkage for affected sib-pairs at two linked loci.
    Genet Epidemiol. 2006 Apr;30(3):191-208 PMID: 16385470
  15. Improving estimates of genetic maps: a meta-analysis-based approach.
    Genet Epidemiol. 2007 Jul;31(5):408-16 PMID: 17443710
  16. Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known.
    Genet Epidemiol. 2006 Jul;30(5):384-96 PMID: 16685713
  17. Improving estimates of genetic maps: a maximum likelihood approach.
    Biometrics. 2006 Sep;62(3):728-34 PMID: 16984314
Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.7156307
Email
[email protected]
Published
2007-12-00
Epub
2007-00-07
Pages
1783-6
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC2099587
Subset
IM
Grants
Intramural NIH HHS · Z01 HG000040 · United States
NIGMS NIH HHS · GM080221 · United States
NIGMS NIH HHS · R01 GM080221 · United States
NIAAA NIH HHS · K25 AA015346 · United States
NHGRI NIH HHS · R01 HG002651 · United States
NHGRI NIH HHS · HG003229 · United States
NHGRI NIH HHS · HG002651 · United States
NIAAA NIH HHS · AA015346 · United States
NIMH NIH HHS · U24 MH068457 · United States
NIMH NIH HHS · MH068457 · United States
NHGRI NIH HHS · R01 HG003229 · United States
NHGRI NIH HHS · T32 HG000040 · United States
External Links
PubMed source DOI: 10.1101/gr.7156307 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2