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PMID: 18052103 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Progress and challenges in selected areas of tobacco carcinogenesis.

Chemical research in toxicology ·Vol. 21 ·No. 1 ·2008-01-00 ·Pages 160-71

Hecht SS

Abstract

Tobacco use continues to be a major cause of cancer in the developed world, and despite significant progress in this country in tobacco control, which is driving a decrease in cancer mortality, there are still over 1 billion smokers in the world. This perspective discusses some selected issues in tobacco carcinogenesis focusing on progress during the 20 years of publication of Chemical Research in Toxicology. The topics covered include metabolism and DNA modification by tobacco-specific nitrosamines, tobacco carcinogen biomarkers, an unidentified DNA ethylating agent in cigarette smoke, mutations in the K-RAS and p53 gene in tobacco-induced lung cancer and their possible relationship to specific carcinogens, secondhand smoke and lung cancer, emerging issues in smokeless tobacco use, and a conceptual model for understanding tobacco carcinogenesis. It is hoped that a better understanding of mechanisms of tobacco-induced cancer will lead to new and useful approaches for the prevention of lung cancer and other cancers caused by tobacco use.

MeSH Terms
Alkylation Animals Biomarkers Carcinogens/chemistry,toxicity DNA Adducts/drug effects Genes, ras/genetics Humans Lung Neoplasms/chemically induced,genetics Mutation/physiology Nitrosamines/chemistry,toxicity Smoke/adverse effects,analysis Tobacco/chemistry,toxicity Tobacco Smoke Pollution/adverse effects Tobacco, Smokeless/adverse effects
Chemicals
Biomarkers Carcinogens DNA Adducts Nitrosamines Smoke Tobacco Smoke Pollution
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hecht Stephen S
University of Minnesota Cancer Center, MMC 806, Minneapolis, Minnesota 55455, USA. [email protected]
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Article Info
Journal
Chemical research in toxicology
Abbr.
Chem Res Toxicol
ISSN
0893-228X
DOI
10.1021/tx7002068
Email
[email protected]
Published
2008-01-00
Epub
2007-00-04
Pages
160-71
Language
English
Region
United States
NLM ID
8807448
PMCID
PMC2556958
Subset
IM
Grants
NIDA NIH HHS · P50 DA013333-019001 · United States
NCI NIH HHS · CA-92025 · United States
NCI NIH HHS · R01 CA092025-01 · United States
NIDA NIH HHS · P50 DA013333 · United States
NCI NIH HHS · R01 CA081301-01 · United States
NCI NIH HHS · CA-81301 · United States
NCI NIH HHS · R01 CA092025 · United States
NIDA NIH HHS · DA-13333 · United States
NCI NIH HHS · R37 CA081301 · United States
NCI NIH HHS · R01 CA081301 · United States
External Links
PubMed source DOI: 10.1021/tx7002068 PMC Full Text View journal details
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