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PMID: 18103399 Published · ppublish English Journal Article

The associative reactions of pneumonia virus of mice and influenza viruses; the effects of pH and electrolytes upon virus-host cell combinations.

The Journal of experimental medicine ·Vol. 88 ·No. 6 ·1948-12-00 ·Pages 621-44

DAVENPORT FM, HORSFALL FL

Abstract

Combination between PVM and erythrocytes as well as between the influenza viruses and erythrocytes is inhibited at low electrolyte concentrations. Combination between PVM and lung particles as well as between the virus and erythrocytes can be dissociated in solutions of low electrolyte concentration. The rate of elution of influenza virus is decreased under similar conditions. PVM can combine with and be dissociated from erythrocytes repeatedly without affecting the combining capacity of the ceils and does not possess an enzyme-like activity similar to that of the influenza viruses. Because dissociation depends on electrolyte concentration and pH, it appears that the PVM-cell component complex may be in the nature of a weak salt.

Keywords
INFLUENZA/virus PNEUMONIA/virus
MeSH Terms
Animals Electrolytes Erythrocytes Humans Influenza, Human Lung Mice Murine pneumonia virus Orthomyxoviridae Pneumonia Viruses
Chemicals
Electrolytes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
DAVENPORT F M
HORSFALL F L
References (12)
12 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1948-12-00
Pages
621-44
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2135846
Subset
OM
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