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PMID: 18184369 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Neurotrophic factors in Alzheimer's disease: role of axonal transport.

Genes, brain, and behavior ·Vol. 7 Suppl 1 ·2008-02-00 ·Pages 43-56

Schindowski K, Belarbi K, Buée L

Abstract

Neurotrophic factors (NTF) are small, versatile proteins that maintain survival and function to specific neuronal populations. In general, the axonal transport of NTF is important as not all of them are synthesized at the site of its action. Nerve growth factor (NGF), for instance, is produced in the neocortex and the hippocampus and then retrogradely transported to the cholinergic neurons of the basal forebrain. Neurodegenerative dementias like Alzheimer's disease (AD) are linked to deficits in axonal transport. Furthermore, they are also associated with imbalanced distribution and dysregulation of NTF. In particular, brain-derived neurotrophic factor (BDNF) plays a crucial role in cognition, learning and memory formation by modulating synaptic plasticity and is, therefore, a critical molecule in dementia and neurodegenerative diseases. Here, we review the changes of NTF expression and distribution (NGF, BDNF, neurotrophin-3, neurotrophin-4/5 and fibroblast growth factor-2) and their receptors [tropomyosin-related kinase (Trk)A, TrkB, TrkC and p75(NTR)] in AD and AD models. In addition, we focus on the interaction with neuropathological hallmarks Tau/neurofibrillary tangle and amyloid-beta (Abeta)/amyloid plaque pathology and their influence on axonal transport processes in order to unify AD-specific cholinergic degeneration and Tau and Abeta misfolding through NTF pathophysiology.

MeSH Terms
Alzheimer Disease/metabolism,pathology Animals Axonal Transport Brain/metabolism,pathology Humans Nerve Growth Factors/metabolism Receptors, Nerve Growth Factor/metabolism
Chemicals
Nerve Growth Factors Receptors, Nerve Growth Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schindowski K
Institut National de la Santé et de la Research Médicale U837, Université Lille 2, Lille Cedex, France. [email protected]
Belarbi K
Buée L
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Article Info
Journal
Genes, brain, and behavior
Abbr.
Genes Brain Behav
ISSN
1601-183X
DOI
10.1111/j.1601-183X.2007.00378.x
Email
[email protected]
Published
2008-02-00
Pages
43-56
Language
English
Region
England
NLM ID
101129617
PMCID
PMC2228393
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1601-183X.2007.00378.x PMC Full Text View journal details
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