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PMID: 18278431 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Metabolism of halophilic archaea.

Extremophiles : life under extreme conditions ·Vol. 12 ·No. 2 ·2008-03-00 ·Pages 177-96

Falb M, Müller K, Königsmaier L, Oberwinkler T, Horn P, von Gronau S, Gonzalez O, Pfeiffer F, Bornberg-Bauer E, Oesterhelt D

Abstract

In spite of their common hypersaline environment, halophilic archaea are surprisingly different in their nutritional demands and metabolic pathways. The metabolic diversity of halophilic archaea was investigated at the genomic level through systematic metabolic reconstruction and comparative analysis of four completely sequenced species: Halobacterium salinarum, Haloarcula marismortui, Haloquadratum walsbyi, and the haloalkaliphile Natronomonas pharaonis. The comparative study reveals different sets of enzyme genes amongst halophilic archaea, e.g. in glycerol degradation, pentose metabolism, and folate synthesis. The carefully assessed metabolic data represent a reliable resource for future system biology approaches as it also links to current experimental data on (halo)archaea from the literature.

MeSH Terms
Euryarchaeota/physiology Folic Acid/biosynthesis Genome, Archaeal/physiology Glycerol/metabolism Pentoses/metabolism
Chemicals
Pentoses Folic Acid Glycerol
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Falb Michaela
Department of Membrane Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Müller Kerstin
Königsmaier Lisa
Oberwinkler Tanja
Horn Patrick
von Gronau Susanne
Gonzalez Orland
Pfeiffer Friedhelm
Bornberg-Bauer Erich
Oesterhelt Dieter
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Article Info
Journal
Extremophiles : life under extreme conditions
Abbr.
Extremophiles
ISSN
1431-0651
DOI
10.1007/s00792-008-0138-x
Published
2008-03-00
Epub
2008-00-16
Pages
177-96
Language
English
Region
Germany
NLM ID
9706854
PMCID
PMC2262144
Subset
IM
External Links
PubMed source DOI: 10.1007/s00792-008-0138-x PMC Full Text View journal details
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