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PMID: 18317565 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.

The Journal of clinical investigation ·Vol. 118 ·No. 3 ·2008-03-00 ·Pages 829-38

Postic C, Girard J

Abstract

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (i) fatty liver (hepatic steatosis); (ii) steatosis with inflammation and necrosis; and (iii) cirrhosis. Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex, recent animal models have shown that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD. This review discusses recent advances in the field.

MeSH Terms
Acetyl-CoA Carboxylase/antagonists & inhibitors Acetyltransferases/antagonists & inhibitors Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Fatty Acid Synthases/physiology Fatty Acids/biosynthesis Fatty Liver/etiology,metabolism,prevention & control Humans Insulin Resistance Lipoproteins, VLDL/biosynthesis Liver/metabolism Mice Mice, Transgenic Nuclear Proteins/physiology Stearoyl-CoA Desaturase/deficiency Transcription Factors/physiology Triglycerides/biosynthesis
Chemicals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Fatty Acids Lipoproteins, VLDL Mlxipl protein, mouse Nuclear Proteins Transcription Factors Triglycerides SCD1 protein, human Stearoyl-CoA Desaturase Acetyltransferases aminoglycoside N1-acetyltransferase Fatty Acid Synthases ACACB protein, human Acetyl-CoA Carboxylase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Postic Catherine
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. [email protected]
Girard Jean
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI34275
Email
[email protected]
Published
2008-03-00
Pages
829-38
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC2254980
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI34275 PMC Full Text View journal details
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