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PMID: 1833772 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antioncogenic effect of adenovirus E1A in human tumor cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 20 ·1991-10-15 ·Pages 9077-81

Frisch SM

Abstract

Stable expression of the adenovirus 5 E1A gene reduced anchorage-independent growth and tumorigenic potential, caused cytoskeletal reorganization, induced flat morphology, and restored contact inhibition in three human tumor cell lines. By these criteria, E1A appears to be functionally indistinguishable from a tumor suppressor gene in this context. The apparent paradox accorded by the observations of the ability of E1A to transform rodent cells in cooperation with other oncogenes suggests that E1A may be the prototype of a class of growth-regulatory proteins having context-specific transforming and antioncogenic activities.

Related Genes
E1A
MeSH Terms
Adenovirus Early Proteins Adenoviruses, Human/genetics Animals Antigens, Viral, Tumor/metabolism Antineoplastic Agents Cell Division Cell Line Fibrosarcoma/pathology Genes, Tumor Suppressor Genes, Viral HeLa Cells Humans Melanoma/pathology Mice Mice, Nude Neoplasm Transplantation Oncogene Proteins, Viral/genetics,isolation & purification,metabolism Recombinant Proteins/isolation & purification,metabolism Transfection Transplantation, Heterologous
Chemicals
Adenovirus Early Proteins Antigens, Viral, Tumor Antineoplastic Agents Oncogene Proteins, Viral Recombinant Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Frisch S M
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.20.9077
Published
1991-10-15
Pages
9077-81
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52655
Subset
IM
Grants
NIGMS NIH HHS · R29 GM 44573 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.20.9077 PMC Full Text View journal details
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